In the past 10 years, we have witnessed major advances in clinical immunology. Newborn
screening for severe combined immunodeficiency has become universal in the United …

Introduction Patients with hematological malignancies (HMs), like chronic lymphocytic
leukemia (CLL), multiple myeloma (MM), and non-Hodgkin lymphoma (NHL), have a high …

Second-line treatments of autoimmune cytopenias (AC) are not well-defined in children.
Mycophenolate mofetil (MMF) is an immunosuppressant agent that has been demonstrated …

Background Primary immunodeficiency (PI) is a group of heterogeneous disorders resulting
from immune system defects. Over 70% of PI is undiagnosed, leading to increased mortality …

ABSTRACT METTL7A is a protein-coding gene expected to be associated with methylation,
and its expression disorder is associated with a range of diseases. However, few research …

The triadic interplay between sleep, immunity, and cancer represents a growing area of
biomedical research with significant clinical implications. This review synthesizes the current …

PIWI-interacting RNA (piRNA) is the most abundant small non-coding RNA in animal cells,
typically 26–31 nucleotides in length and it binds with PIWI proteins, a subfamily of …

Objectives In 30 years, monoclonal antibodies (mAbs) and immune checkpoint inhibitors
(ICPIs) have enhanced cancer survival and quality of life. Limited knowledge exists …

Introduction Secondary antibody deficiencies (SAD) are often a side effect of specific
therapies that target B cells directly or affect the antibody response indirectly. Treatment of …

Simple Summary Primary immunodeficiencies (PIDs) and secondary immunodeficiencies
(SIDs) weaken the immune system, making people prone to infections and possibly affecting …