[PDF][PDF] Lessons learned from GWAS of asthma
Asthma is a common complex disease of the airways. Genome-wide association studies
(GWASs) of asthma have identified many risk alleles and loci that have been replicated in …
(GWASs) of asthma have identified many risk alleles and loci that have been replicated in …
Lessons from ten years of genome‐wide association studies of asthma
CT Vicente, JA Revez… - Clinical & translational …, 2017 - Wiley Online Library
Twenty‐five genome‐wide association studies (GWAS) of asthma were published between
2007 and 2016, the largest with a sample size of 157242 individuals. Across these studies …
2007 and 2016, the largest with a sample size of 157242 individuals. Across these studies …
Lung eQTLs to help reveal the molecular underpinnings of asthma
Genome-wide association studies (GWAS) have identified loci reproducibly associated with
pulmonary diseases; however, the molecular mechanism underlying these associations are …
pulmonary diseases; however, the molecular mechanism underlying these associations are …
Genome-wide association study of lung function decline in adults with and without asthma
M Imboden, E Bouzigon, I Curjuric, A Ramasamy… - Journal of allergy and …, 2012 - Elsevier
BACKGROUND: Genome-wide association studies have identified determinants of chronic
obstructive pulmonary disease, asthma, and lung function level; however, none have …
obstructive pulmonary disease, asthma, and lung function level; however, none have …
Genetic polymorphisms and associated susceptibility to asthma
ME March, PMA Sleiman… - International journal of …, 2013 - Taylor & Francis
As complex common diseases, asthma and allergic diseases are caused by the interaction
of multiple genetic variants with a variety of environmental factors. Candidate-gene studies …
of multiple genetic variants with a variety of environmental factors. Candidate-gene studies …
Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthma
JS Ried, H Baurecht, F Stückler, J Krumsiek, C Gieger… - Allergy, 2013 - Wiley Online Library
Background Genome‐wide association studies (GWAS) have identified many risk loci for
asthma, but effect sizes are small, and in most cases, the biological mechanisms are …
asthma, but effect sizes are small, and in most cases, the biological mechanisms are …
HLA‐DQ strikes again: Genome‐wide association study further confirms HLA‐DQ in the diagnosis of asthma among adults
Background Asthma is a common chronic respiratory disease in children and adults. An
important genetic component to asthma susceptibility has long been recognized, most …
important genetic component to asthma susceptibility has long been recognized, most …
Phosphodiesterase 11A (PDE11A) Gene Defects in Patients with ACTH-Independent Macronodular Adrenal Hyperplasia (AIMAH): Functional Variants May …
D Vezzosi, R Libé, C Baudry… - The Journal of …, 2012 - academic.oup.com
Context: Phosphodiesterases (PDEs) are key regulatory enzymes of intracellular cAMP
levels. PDE11A function has been linked to predisposition to adrenocortical tumors …
levels. PDE11A function has been linked to predisposition to adrenocortical tumors …
[HTML][HTML] The genetics of asthma and allergic disorders
ME March, PMA Sleiman… - Discovery …, 2011 - discoverymedicine.com
Asthma and allergic diseases are complex conditions caused by a combination of genetic
and environmental factors. More than 100 genes have been associated with asthma and …
and environmental factors. More than 100 genes have been associated with asthma and …
Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen
O Ceyhan, K Birsoy, CS Hoffman - Chemistry & biology, 2012 - cell.com
The biological roles of cyclic nucleotide phosphodiesterase 11 (PDE11) enzymes are poorly
understood, in part due to the lack of selective inhibitors. To address the need for such …
understood, in part due to the lack of selective inhibitors. To address the need for such …