During the last century, there has been an increasing prevalence of hyperuricaemia noted in
many populations. While uric acid is usually discussed in the context of gout …

Gout is a common hyperuricaemic metabolic condition that leads to painful inflammatory
arthritis and a high comorbidity burden, especially cardiometabolic-renal (CMR) conditions …

Background and objectives Recent studies have shown that hyperuricemia is commonly
associated with dyslipidemia, cardiovascular diseases, hypertension and metabolic …

Objective To map the diverse health outcomes associated with serum uric acid (SUA) levels.
Design Umbrella review. Data sources Medline, Embase, Cochrane Database of Systematic …

Background: Mendelian randomization (MR) studies investigate the effect of genetic
variation in levels of an exposure on an outcome, thereby using genetic variation as an …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Abstract The Generation R Study is a population-based prospective cohort study from fetal
life until adulthood. The study is designed to identify early environmental and genetic causes …

Objective Circulating uric acid levels were associated with insulin resistance, but the
causality is unclear. We aimed to investigate the association between plasma uric acid and …

We aimed to investigate the causal effect of circulating uric acid concentrations on type 2
diabetes risk. A Mendelian randomization study was performed using a genetic score with …

Objective: The aim of this study was to explore the latest prevalence of hyperuricemia and
influencing factors in Chinese rural population. Methods: A survey was conducted from July …