Abstract The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …

Carcinogenesis is a mechanistically complex and variable process with a plethora of
underlying genetic causes. Cancer development comprises a multitude of steps that occur …

Epidemiological studies have revealed that a diet rich in plant-derived foods has a protective
effect on human health. Identifying bioactive dietary constituents is an active area of …

The mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs by
relaying extracellular signals to intracellular responses. In mammals, there are more than a …

The 90 kDa ribosomal S6 kinase (RSK) family of proteins is a group of highly conserved
Ser/Thr kinases that regulate diverse cellular processes, such as cell growth, cell motility …

Cisplatin is a widely used chemotherapeutic agent for treatment of various cancers.
However, treatment with cisplatin is associated with drug resistance and several adverse …

The RSK (90 kDa ribosomal S6 kinase) family comprises a group of highly related
serine/threonine kinases that regulate diverse cellular processes, including cell growth …

Androgens, acting through the androgen receptor (AR), are responsible for the development
of the male phenotype during embryogenesis, the achievement of sexual maturation at …

Abstract Kaempferol (3, 5, 7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) is a
flavonoid found in many edible plants (eg, tea, broccoli, cabbage, kale, beans, endive, leek …

Background Head and neck squamous cell cancer (HNSCC) is the most common cancer
associated with chewing tobacco, in the world. As this is divided in to sites and subsites, it …