Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds

HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …

Clinical effects of curcumin in enhancing cancer therapy: A systematic review

K Mansouri, S Rasoulpoor, A Daneshkhah, S Abolfathi… - BMC cancer, 2020 - Springer
Background Curcumin is herbal compound that has been shown to have anti-cancer effects
in pre-clinical and clinical studies. The anti-cancer effects of curcumin include inhibiting the …

Chemotherapy-induced peripheral neuropathy: epidemiology, pathomechanisms and treatment

J Burgess, M Ferdousi, D Gosal, C Boon… - Oncology and …, 2021 - Springer
Purpose This review provides an update on the current clinical, epidemiological and
pathophysiological evidence alongside the diagnostic, prevention and treatment approach …

[HTML][HTML] Polyphenols as antitumor agents targeting key players in cancer-driving signaling pathways

MH Cháirez-Ramírez, KG de la Cruz-López… - Frontiers in …, 2021 - frontiersin.org
Polyphenols constitute an important group of natural products that are traditionally
associated with a wide range of bioactivities. These are usually found in low concentrations …

[HTML][HTML] Impacts of turmeric and its principal bioactive curcumin on human health: Pharmaceutical, medicinal, and food applications: A comprehensive review

MT El-Saadony, T Yang, SA Korma, M Sitohy… - Frontiers in …, 2023 - frontiersin.org
The yellow polyphenolic pigment known as curcumin, originating from the rhizome of the
turmeric plant Curcuma longa L., has been utilized for ages in ancient medicine, as well as …

Curcumin and colorectal cancer: from basic to clinical evidences

M Pricci, B Girardi, F Giorgio, G Losurdo… - International journal of …, 2020 - mdpi.com
Curcumin diffuses through cell membranes into the endoplasmic reticulum, mitochondria,
and nucleus, where it exerts actions, as an antioxidant property. Therefore, its use has been …

Effects and mechanisms of curcumin for the prevention and management of cancers: An updated review

ZJ Yang, SY Huang, DD Zhou, RG Xiong, CN Zhao… - Antioxidants, 2022 - mdpi.com
Cancer is the leading cause of death in the world. Curcumin is the main ingredient in
turmeric (Curcuma longa L.), and is widely used in the food industry. It shows anticancer …

Curcumin activates a ROS/KEAP1/NRF2/miR-34a/b/c cascade to suppress colorectal cancer metastasis

C Liu, M Rokavec, Z Huang, H Hermeking - Cell Death & Differentiation, 2023 - nature.com
Curcumin, a natural phytochemical isolated from tumeric roots, represents a candidate for
prevention and therapy of colorectal cancer/CRC. However, the exact mechanism of action …

The Notch signaling pathway: a potential target for cancer immunotherapy

X Li, X Yan, Y Wang, B Kaur, H Han, J Yu - Journal of Hematology & …, 2023 - Springer
Dysregulation of the Notch signaling pathway, which is highly conserved across species,
can drive aberrant epigenetic modification, transcription, and translation. Defective gene …

Role of turmeric and curcumin in prevention and treatment of chronic diseases: Lessons learned from clinical trials

AB Kunnumakkara, M Hegde, D Parama… - ACS Pharmacology & …, 2023 - ACS Publications
Turmeric (Curcuma longa) has been used for thousands of years for the prevention and
treatment of various chronic diseases. Curcumin is just one of> 200 ingredients in turmeric …