Vascular remodeling refers to alterations in the structure of resistance vessels contributing to
elevated systemic vascular resistance in hypertension. We start with some historical aspects …

Tumor necrosis factor alpha (TNFα) is the most widely studied pleiotropic cytokine of the
TNF superfamily. In pathophysiological conditions, generation of TNFα at high levels leads …

TWEAK is a multifunctional cytokine that controls many cellular activities including
proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation. TWEAK …

Primary graft dysfunction (PGD) remains the leading cause of early mortality post-heart
transplantation. Despite improvements in mechanical circulatory support and critical care …

Interleukins are considered to be key players in the chronic vascular inflammatory response
that is typical of atherosclerosis. Thus, the expression of proinflammatory interleukins and …

Cardiovascular disease (CVD) is the leading cause of death worldwide. CVD includes a
group of disorders of the heart and blood vessels such as myocardial infarction, ischemic …

Myocardial cell death is a key element in the pathogenesis and progression of various
etiological cardiomyopathies such as ischemia-reperfusion, toxic exposure, and various …

Cardiac hypertrophy, initiated by a variety of physiological or pathological stimuli
(hemodynamic or hormonal stimulation or infarction), is a critical early adaptive …

TNF α administration mimics ischemic preconditioning and neutralizing antibodies to TNFα
and IL-1 β abolish exercise-induced preconditioning. However, the pharmacology of TNFα's …

In this study, we used deoxyribozyme (DNAzyme) functionalized gold nanoparticles (AuNPs)
to catalytically silence tumor necrosis factor-α (TNF-α) in vivo as a potential therapeutic for …