Towards an integrated understanding of dietary phenotypes

D Raubenheimer, R Hou, Y Dong… - … Transactions of the …, 2023 - royalsocietypublishing.org
Diet and nutrition comprise a complex, multi-faceted interface between animal biology and
food environments. With accumulating information on the many facets of this association …

[HTML][HTML] Going beyond established model systems of Alzheimer's disease: companion animals provide novel insights into the neurobiology of aging

AA de Sousa, BA Rigby Dames, EC Graff… - Communications …, 2023 - nature.com
Alzheimer's disease (AD) is characterized by brain plaques, tangles, and cognitive
impairment. AD is one of the most common age-related dementias in humans. Progress in …

Neural signatures of natural behaviour in socializing macaques

C Testard, S Tremblay, F Parodi, RW DiTullio… - Nature, 2024 - nature.com
Our understanding of the neurobiology of primate behaviour largely derives from artificial
tasks in highly controlled laboratory settings, overlooking most natural behaviours that …

Ecological disturbance alters the adaptive benefits of social ties

C Testard, C Shergold, A Acevedo-Ithier, J Hart… - Science, 2024 - science.org
Extreme weather events radically alter ecosystems. When ecological damage persists,
selective pressures on individuals can change, leading to phenotypic adjustments. For …

[HTML][HTML] An evolutionary model for the ancient origins of polycystic ovary syndrome

DA Dumesic, DH Abbott, GD Chazenbalk - Journal of Clinical Medicine, 2023 - mdpi.com
Polycystic ovary syndrome (PCOS) is a common endocrinopathy of reproductive-aged
women, characterized by hyperandrogenism, oligo-anovulation and insulin resistance and …

The biology of aging in a social world: Insights from free-ranging rhesus macaques

LE Newman, C Testard, AR DeCasien, KL Chiou… - Neuroscience & …, 2023 - Elsevier
Social adversity can increase the age-associated risk of disease and death, yet the
biological mechanisms that link social adversities to aging remain poorly understood. Long …

Natural animal populations as model systems for understanding early life adversity effects on aging

SK Patterson, RM Petersen, LJN Brent… - Integrative and …, 2023 - academic.oup.com
Adverse experiences in early life are associated with aging-related disease risk and
mortality across many species. In humans, confounding factors, as well as the difficulty of …

Geosmin, a Food-and Water-Deteriorating Sesquiterpenoid and Ambivalent Semiochemical, Activates Evolutionary Conserved Receptor OR11A1

L Ball, T Frey, F Haag, S Frank… - Journal of Agricultural …, 2024 - ACS Publications
Geosmin, a ubiquitous volatile sesquiterpenoid of microbiological origin, is causative for
deteriorating the quality of many foods, beverages, and drinking water, by eliciting an …

[HTML][HTML] Evolutionary and biomedical implications of sex differences in the primate brain transcriptome

AR DeCasien, KL Chiou, C Testard, A Mercer… - Cell Genomics, 2024 - cell.com
Humans exhibit sex differences in the prevalence of many neurodevelopmental disorders
and neurodegenerative diseases. Here, we generated one of the largest multi-brain-region …

Maintenance of caecal homeostasis by diverse adaptive immune cells in the rhesus macaque

X Castro Dopico, M Guryleva… - Clinical & …, 2024 - Wiley Online Library
Objectives The caecum bridges the small and large intestine and plays a front‐line role in
discriminating gastrointestinal antigens. Although dysregulated in acute and chronic …