[HTML][HTML] A systems and computational biology perspective on advancing CAR therapy
V Tserunyan, SD Finley - Seminars in Cancer Biology, 2023 - Elsevier
In the recent decades, chimeric antigen receptor (CAR) therapy signaled a new
revolutionary approach to cancer treatment. This method seeks to engineer immune cells …
revolutionary approach to cancer treatment. This method seeks to engineer immune cells …
Mechanisms of resistance to CAR-T cell immunotherapy: Insights from a mathematical model
DS Santurio, EA Paixão, LRC Barros… - Applied Mathematical …, 2024 - Elsevier
Abstract Chimeric Antigen Receptor (CAR)-T cell therapy long-term follow-up studies
revealed non-durable remissions in a significant number of patients. Some of the …
revealed non-durable remissions in a significant number of patients. Some of the …
Effects of a differentiating therapy on cancer-stem-cell-driven tumors
J Fotinós, L Barberis, CA Condat - Journal of Theoretical Biology, 2023 - Elsevier
The growth of many solid tumors has been found to be driven by chemo-and radiotherapy-
resistant cancer stem cells (CSCs). A suitable therapeutic avenue in these cases may …
resistant cancer stem cells (CSCs). A suitable therapeutic avenue in these cases may …
Mathematical Modeling of Interleukin-15 Therapy for Human Immunodeficiency Virus
J Cody - 2023 - search.proquest.com
Abstract Interleukin-15 (IL-15) is a cytokine that promotes maintenance and activation of
cytotoxic immune cells. Therapeutic IL-15 stimulates these cells to fight cancer and chronic …
cytotoxic immune cells. Therapeutic IL-15 stimulates these cells to fight cancer and chronic …