Spirocyclic scaffolds are incorporated in various approved drugs and drug candidates. The
increasing interest in less planar bioactive compounds has given rise to the development of …

The development of novel synthetic strategies to form new chemical entities in a
stereoselective manner is an ongoing significant objective in organic and medicinal …

A quaternary carbon bears four other carbon substituents or combination of four non-
hydrogen substituents at four vertices of a tetrahedron. The spirocyclic quaternary carbon …

The development of efficient and straightforward methods for obtaining all optically active
isomers of structurally rigid spirocycles from readily available starting materials is of great …

Catalytic functionalization of alkynes with organoboron reagents provides a straightforward
access to stereochemically defined multisubstituted alkenes, which are structural motifs …

Aromatic ring isosteres and rigidified saturated hydrocarbons are important motifs to enable
drug discovery. Herein we disclose [2]-ladderanes as a class of meta-substituted aromatic …

The catalytic enantioselective construction of three-dimensional molecular architectures
from planar aromatics such as quinolines is of great interest and importance from the …

Spirocyclic frameworks have attracted synthetic practitioners due to their unique three-
dimensional assembly, improved metabolic stability, solubility, and increased molecular …

We report a general visible-light-mediated strategy that enables the construction of complex
C (sp3)-rich N-heterospirocycles from feedstock aliphatic ketones and aldehydes with a …

In recent years, spiro compounds have attracted significant interest in medicinal chemistry
due to their numerous biological activities attributed primarily to their versatility and structural …