Metastatic melanoma is among the most enigmatic advanced cancers to clinically manage
despite immense progress in the way of available therapeutic options and historic …

Metabolic reprogramming provides tumors with an energy source and biofuel to support
their survival in the malignant microenvironment. Extensive research into the intrinsic …

Background Members of the cellular communication network family (CCN) of matricellular
proteins, like CCN1, have long been implicated in the regulation of cellular processes …

Simple Summary Despite the advancement of molecular biology and Next-Generation
Sequencing (NGS), the study of the tumor microenvironment continues to have paradigmatic …

Hippo was first identified in a genetic screen as a protein that suppressed proliferation and
cell growth. Subsequently, it was shown that hippo acted in a so-called canonical cascade to …

Advances in melanoma research have unveiled critical insights into its genetic and
molecular landscape, leading to significant therapeutic innovations. This review explores the …