Ultra-high field imaging of the amygdala–a narrative review

CF Kirstein, O Güntürkün, S Ocklenburg - Neuroscience & Biobehavioral …, 2023 - Elsevier
The amygdala is an evolutionarily conserved core structure in emotion processing and one
of the key regions of interest in affective neuroscience. Results of neuroimaging studies …

Agomelatine for the treatment of generalized anxiety disorder: focus on its distinctive mechanism of action

MJ Millan - Therapeutic Advances in Psychopharmacology, 2022 - journals.sagepub.com
Generalized anxiety disorder (GAD), the most frequently diagnosed form of anxiety, is
usually treated by cognitive-behavioural approaches or medication; in particular …

A meta-analysis of conditioned fear generalization in anxiety-related disorders

SE Cooper, EAM van Dis, MA Hagenaars… - …, 2022 - nature.com
Generalization of conditioned fear is adaptive in some situations but maladaptive when fear
excessively generalizes to innocuous stimuli with incidental resemblance to a genuine …

Effects of RU486 in treatment of traumatic stress-induced glucocorticoid dysregulation and fear-related abnormalities: early versus late intervention

CC Lin, PY Cheng, M Hsiao, YP Liu - International journal of molecular …, 2022 - mdpi.com
Central glucocorticoid receptor (GR) activity is enhanced following traumatic events, playing
a key role in the stress-related cognitive abnormalities of posttraumatic stress disorder …

Impact of stress on brain morphology: insights into structural biomarkers of stress-related disorders

R Andero, M Cano, I Marin-Blasco… - Current …, 2024 - ingentaconnect.com
Exposure to acute and chronic stress has a broad range of structural effects on the brain.
The brain areas commonly targeted in the stress response models include the …

Threat vigilance and intrinsic amygdala connectivity

PA Kirk, AJ Holmes, OJ Robinson - Human brain mapping, 2022 - Wiley Online Library
A well‐documented amygdala‐dorsomedial prefrontal circuit is theorized to promote
attention to threat (“threat vigilance”). Prior research has implicated a relationship between …

Sometimes I feel the fear of uncertainty: How intolerance of uncertainty and trait anxiety impact fear acquisition, extinction and the return of fear

A Wroblewski, M Hollandt, Y Yang… - International Journal of …, 2022 - Elsevier
It is hypothesized that the ability to discriminate between threat and safety is impaired in
individuals with high dispositional negativity, resulting in maladaptive behavior. A large body …

Intolerance of uncertainty enhances generalisation of cued conditioned threat: An event-related potential study

X Zhou, Y Gu, J Wang, L Huang, Y Lei - Biological Psychology, 2023 - Elsevier
Overgeneralisation is one of the aetiologies of anxiety disorders and is closely associated
with elevated intolerance of uncertainty (IU) levels. However, the underlying mechanisms …

No influence of threat uncertainty on fear generalization

A Aslanidou, M Andreatta, AHK Wong… - …, 2024 - Wiley Online Library
Fear overgeneralization and perceived uncertainty about future outcomes have been
suggested as risk factors for clinical anxiety. However, little is known regarding how they …

Individual differences in contextual threat generalisation and uncertainty: The role of intolerance of uncertainty

X Zhou, Y Gu, L Huang, Y Lei - International Journal of …, 2023 - Wiley Online Library
Threat generalisation is an adaptive process that is essential for individual survival. In
contrast, over‐generalisation is a pathological process that underlies the development of …