Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …

Fibrosis, or tissue scarring, develops as a pathological deviation from the physiological
wound healing response and can occur in various organs such as the heart, lung, liver …

From the clinical standpoint, systemic sclerosis (SSc) is characterized by skin and internal
organ fibrosis, diffuse fibroproliferative vascular modifications, and autoimmunity. Clinical …

Abstract Background Systemic sclerosis (SSc) is a disorder characterized by immune system
alterations, vasculopathy and fibrosis. SSc-related interstitial lung disease (ILD) represents a …

Systemic sclerosis (SSc) is an idiopathic systemic autoimmune disease. It is characterized
by a triad of hallmarks: immune dysfunction, fibrosis and vasculopathy. Immune dysfunction …

Systemic autoimmune rheumatic diseases (SARDs) exhibit extensive heterogeneity in
clinical presentation, disease course, and treatment response. Therefore, precision …

Autoimmunity refers to the phenomenon that the body's immune system produces antibodies
or sensitized lymphocytes to its own tissues to cause an immune response. Immune …

Systemic sclerosis is an autoimmune disorder characterized by inflammation and a
progressive fibrosis affecting the skin and visceral organs. Over the last two decades, it …

Systemic sclerosis (SSc, scleroderma) is a complex multisystem disease characterized by
autoimmunity, vasculopathy, and most notably, fibrosis. Multiple lines of evidence …

Objective Genome‐wide gene expression studies implicate macrophages as mediators of
fibrosis in systemic sclerosis (SS c), but little is known about how these cells contribute to …