[HTML][HTML] A botulinum toxin–derived targeted secretion inhibitor downregulates the GH/IGF1 axis
E Somm, N Bonnet, A Martinez… - The Journal of …, 2012 - Am Soc Clin Investig
Botulinum neurotoxins (BoNTs) are zinc endopeptidases that block release of the
neurotransmitter acetylcholine in neuromuscular synapses through cleavage of soluble N …
neurotransmitter acetylcholine in neuromuscular synapses through cleavage of soluble N …
Pituitary Hormones as Neurotrophic Signals: Update on Hypothalamic Differentiation in Genetic Models of Altered Feedback2
CJ Phelps, DL Hurley - … of the Society for Experimental Biology …, 1999 - Wiley Online Library
Studies of mutant mice that are growth hormone (GH)‐and prolactin (PRL)‐deficient have
provided evidence that these pituitary hormones have trophic, as well as dynamic, feedback …
provided evidence that these pituitary hormones have trophic, as well as dynamic, feedback …
Effect of cadmium on 24-h variations in hypothalamic dopamine and serotonin metabolism in adult male rats
A Lafuente, A Gonzalez-Carracedo, A Romero… - Experimental brain …, 2003 - Springer
This study was designed to analyze the possible cadmium effects on time-of-day variations
of anterior, mediobasal, and posterior hypothalamic contents of dopamine (DA), serotonin (5 …
of anterior, mediobasal, and posterior hypothalamic contents of dopamine (DA), serotonin (5 …
Growth hormone‐releasing hormone‐producing and dopaminergic neurones in the mouse arcuate nucleus are independently regulated populations
CJ Phelps, MI Romero… - Journal of …, 2003 - Wiley Online Library
Differentiation of hypophysiotropic neurones that regulate the secretion of growth hormone
(GH) and prolactin is influenced by GH and prolactin. Genetic GH and prolactin deficiency in …
(GH) and prolactin is influenced by GH and prolactin. Genetic GH and prolactin deficiency in …
[PDF][PDF] Increased lactotrophs despite decreased somatotrophs in the dwarf (dw/dw) rat: a defect in the regulation of lactotroph/somatotroph cell fate?
T Tierney, I Robinson - Journal of endocrinology, 2002 - Citeseer
The dwarf (dw/dw) rat differs from all other rodent models of GH deficiency in that its pituitary
prolactin (PRL) content is normal or even increased. We have now studied this throughout …
prolactin (PRL) content is normal or even increased. We have now studied this throughout …
Human chorionic gonadotropin (hCG) beta-core fragment is produced by degradation of hCG or free hCG beta in gestational trophoblastic tumors: a possible marker …
T Okamoto, K Matsuo, R Niu, M Osawa… - Journal of …, 2001 - joe.bioscientifica.com
The dwarf (dw/dw) rat differs from all other rodent models of GH deficiency in that its pituitary
prolactin (PRL) content is normal or even increased. We have now studied this throughout …
prolactin (PRL) content is normal or even increased. We have now studied this throughout …
The Intermediate Lactotroph: A Morphologically Distinct, Ghrelin-Responsive Pituitary Cell in the Dwarf (dw/dw) Rat
I Huerta-Ocampo, HC Christian, NM Thompson… - …, 2005 - academic.oup.com
Profound somatotroph hypoplasia in the dwarf (dw/dw) rat is accompanied by an estrogen-
dependent induction of prolactin secretion by the GH secretagogue, GHRP-6. Using electron …
dependent induction of prolactin secretion by the GH secretagogue, GHRP-6. Using electron …
Comparative inhibition of the GH/IGF-I axis obtained with either the targeted secretion inhibitor SXN101959 or the somatostatin analog octreotide in growing male rats
E Somm, N Bonnet, P Zizzari, V Tolle, A Toulotte… - …, 2013 - academic.oup.com
Abnormally high GH/IGF-I levels, most often caused by adenomas arising from pituitary
somatotrophs, generate deleterious effects. We recently described a targeted secretion …
somatotrophs, generate deleterious effects. We recently described a targeted secretion …
Reduced hypothalamic neuropeptide Y expression in growth hormone-and prolactin-deficient Ames and Snell dwarf mice
DL Hurley, DV Birch, MC Almond, IJ Estrada… - …, 2003 - academic.oup.com
Neuropeptide Y (NPY)-producing neurons in the hypothalamic arcuate nucleus (ARC) have
been implicated in GH feedback in several studies in rats. Ames (df/df) and Snell (dw/dw) …
been implicated in GH feedback in several studies in rats. Ames (df/df) and Snell (dw/dw) …
Hypothalamic Expression of Human Growth Hormone Induces Post‐Pubertal Hypergonadotrophism in Male Transgenic Growth Retarded Rats
JS Davies, NM Thompson, HC Christian… - Journal of …, 2006 - Wiley Online Library
Growth hormone (GH) is known to regulate peripheral components of the hypothalamo‐
pituitary gonadal (HPG) axis, but it remains unclear whether GH exerts a significant …
pituitary gonadal (HPG) axis, but it remains unclear whether GH exerts a significant …