Metabolic suppression in the ischemic heart is characterized by reduced levels of NAD+ and
ATP. Since NAD+ is required for most metabolic processes that generate ATP, we …

Out-of-hospital cardiac arrest is a leading cause of death in the US, with a mortality rate over
90%. Preclinical studies demonstrate that cooling during cardiopulmonary resuscitation …

Background Outcomes from cardiopulmonary resuscitation (CPR) following sudden cardiac
arrest are suboptimal. Postresuscitation targeted temperature management has been shown …

Therapeutic hypothermia (TH) provides cardioprotection from ischemia/reperfusion (I/R)
injury. However, it remains unknown how TH regulates metabolic recovery. We tested the …

Could the post-inflammatory state that follows cardiac arrest be a mechanistic black swan?
In this issue of Resuscitation, Langeland and colleagues help us understand the potential …