The involvement of long non-coding RNAs in bone

C Aurilia, S Donati, G Palmini, F Miglietta… - International journal of …, 2021 - mdpi.com
A harmonious balance between osteoblast and osteoclast activity guarantees optimal bone
formation and resorption, pathological conditions affecting the bone may arise. In recent …

LncRNAs as a new regulator of chronic musculoskeletal disorder

H Huang, D Xing, Q Zhang, H Li, J Lin, Z He… - Cell …, 2021 - Wiley Online Library
Objectives In recent years, long non‐coding RNAs (lncRNAs) have been found to play a role
in the occurrence, progression and prognosis of chronic musculoskeletal disorders. Design …

Bone marrow mesenchymal stem cells derived exosomal Lnc TUG1 promotes bone fracture recovery via miR-22-5p/Anxa8 axis

W Li, L Li, R Cui, X Chen, H Hu, Y Qiu - Human Cell, 2023 - Springer
Bone fracture healing is a complex physiologic process that involves changes in the
expression of several thousand genes. Long noncoding RNAs (lncRNAs) may have critical …

Epigenetic therapy targeting bone marrow mesenchymal stem cells for age-related bone diseases

Y Zhao, J He, T Qiu, H Zhang, L Liao, X Su - Stem cell research & therapy, 2022 - Springer
As global aging accelerates, the prevention and treatment of age-related bone diseases are
becoming a critical issue. In the process of senescence, bone marrow mesenchymal stem …

Systematic analysis of mRNAs and ncRNAs in BMSCs of senile osteoporosis patients

Y Geng, J Chen, C Chang, Y Zhang, L Duan… - Frontiers in …, 2021 - frontiersin.org
Senile osteoporosis (SOP) is a worldwide age-related disease characterized by the loss of
bone mass and decrease in bone strength. Bone mesenchymal stem cells (BMSCs) play an …

lncRNA PAPPA‐AS1 induces the development of hypertrophic scar by upregulating TLR4 through interacting with TAF15

P Fan, Y Wang, J Li, M Fang - Mediators of Inflammation, 2021 - Wiley Online Library
Hypertrophic scar (HTS) is a complicated pathological process induced mainly by burns and
wounds, with abnormal proliferation of fibroblasts and the transformation of fibroblasts to …

Long non‑coding RNA RP11‑84C13. 1 promotes osteogenic differentiation of bone mesenchymal stem cells and alleviates osteoporosis progression via the miR‑23b …

H Yu, Y Li, J Tang, X Lu, W Hu… - Experimental and …, 2021 - spandidos-publications.com
The objective of the present study was to determine the role of RP11‑84C13. 1 in
osteoporosis (OP) and its molecular mechanism. First, clinical samples were collected from …

LncRNA HOTAIRM1 promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by targeting miR-152-3p/ETS1 axis

X Wang, Y Liu, P Lei - Molecular Biology Reports, 2023 - Springer
Background Bone marrow mesenchymal stem cells (BMSCs) can differentiate into
osteoblasts and thus present a tremendous therapeutic potential in osteoporosis. Here, we …

Epigenetic therapies of osteoporosis

F de Nigris, C Ruosi, G Colella, C Napoli - Bone, 2021 - Elsevier
The study of epigenetics reaches its 50th anniversary, however, its clinical application is
gradually coming into the clinical setting. Osteoporosis is one of the major and widely …

LINC01234 Sponging of the miR-513a-5p/AOX1 Axis is Upregulated in Osteoporosis and Regulates Osteogenic Differentiation of Bone Marrow Mesenchymal Stem …

Z Yan, Q He - Molecular Biotechnology, 2023 - Springer
Non-coding RNAs, including long-chain non-coding RNA (lncRNA) and micro-RNA
(miRNA), have been implicated in osteoporosis (OP) progression by regulating osteoblast …