Cancer development and progression occurs in concert with alterations in the surrounding
stroma. Cancer cells can functionally sculpt their microenvironment through the secretion of …

Natural killer (NK) cells are the predominant innate lymphocyte subsets that mediate anti-
tumor and anti-viral responses, and therefore possess promising clinical utilization. NK cells …

Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …

The contribution of natural killer (NK) cells to immunosurveillance of human cancer remains
debatable. Here, we discuss advances in several areas of human NK cell research, many of …

Simple Summary Innate immune natural killer (NK) cells are capable of killing metastatic
cancer cells without activation by antigen-presenting cells beforehand. The cytotoxic effects …

The emergence of immunotherapy for cancer treatment bears considerable clinical promise.
Nevertheless, many patients remain unresponsive, acquire resistance, or suffer dose …

Dietary plant polysaccharides, one of the main sources of natural polysaccharides, possess
significant cancer prevention activity and potential development value in the food and …

Immune cells, as a consequence of their plasticity, can acquire altered phenotype/functions
within the tumor microenvironment (TME). Some of these aberrant functions include …

Human leukocyte antigen (HLA)-E binds epitopes derived from HLA-A, HLA-B, HLA-C and
HLA-G signal peptides (SPs) and serves as a ligand for CD94/NKG2A and CD94/NKG2C …

Cytokine-based immunotherapy is a promising field in the cancer treatment, since cytokines,
as proteins of the immune system, are able to modulate the host immune response toward …