The intention of the current article is to review the epidemiology with related socioeconomic
costs, pathophysiology, and treatment options for diaphyseal long bone delayed unions and …

Bone grafting is involved in virtually every procedure in reconstructive orthopaedic surgery.
Although autologous bone grafts have excellent biologic and mechanical properties …

Background: Bone marrow aspirated from the iliac crest contains progenitor cells that can be
used to obtain bone-healing of nonunions. However, there is little available information …

Mesenchymal progenitor cells provide a source of cells for the repair of musculoskeletal
tissue. However, in vitro models are needed to study the mechanisms of differentiation of …

The formation, growth, maintenance, and healing of the skeleton require that bone be
formed throughout life. Normal osteoblasts produce bone under a vanety of conditions …

Bone marrow contains osteoblast progenitor cells that can be obtained with aspiration and
appear to arise from a population of pluripotential connective-tissue stem cells. When …

Bone marrow contains a population of rare progenitor cells capable of differentiating into
bone, cartilage, muscle, tendon, and other connective tissues. These cells, referred to as …

During the development of normal bone in the young child, osteoblasts and then
haematopoietic stem cells progressively colonise the cartilaginous matrix, resulting in its …

We have investigated the effects of different growth factors on the proliferation and
osteogenic potential of primary cultures of human bone marrow stromal cells (BMSC) …

Skeletal tissue regeneration requires the interaction of three basic biologic elements: cells,
growth and differentiation factors, and extracellular matrix scaffolds. Therapeutic approaches …