The impact of autoimmune diseases is growing from both a clinical and a laboratory point of
view. Diagnostic assays are now being transferred from dedicated specialised laboratories …

The detection of autoantibodies that target intracellular antigens, commonly termed anti‐
nuclear antibodies (ANA), is a serological hallmark in the diagnosis of systemic autoimmune …

The etiology of autoimmune diseases is due to a combination of genetic predisposition and
environmental factors that alter the expression of immune regulatory genes through various …

It has been more than 50 years since antinuclear antibodies were first discovered and found
to be associated with connective tissue diseases. Since then different methods have been …

Autoantibodies against double-stranded DNA (dsDNA) were first described> 60 years ago
and although they are still one of the most clinically relevant autoantibodies, test results may …

Flow cytometry is a powerful tool in the clinical and research setting for defining the
characteristics of cells or particles utilizing the light scattering properties of analyzed cells or …

Technologies based on surface plasmon resonance (SPR) have allowed rapid, label‐free
characterization of protein‐protein and protein‐small molecule interactions. SPR has …

The methods for detecting and measuring autoantibodies have evolved markedly in recent
years, encompassing three generations of analytical technologies. Many different …

The BioPlex™ 2200 ANA Screen is a fully automated system that determines levels for 13
different autoimmune antibodies of established clinical significance. The objective of this …

Testing for the presence of antinuclear antibodies (ANAs) is a key step in the diagnosis of
systemic lupus erythematosus (SLE) and other systemic autoimmune rheumatic diseases …