Targeting lymphatic function as a novel therapeutic intervention for rheumatoid arthritis
Although clinical outcomes for patients with rheumatoid arthritis (RA) have greatly improved
with the use of biologic and conventional DMARDs, approximately 40% of patients do not …
with the use of biologic and conventional DMARDs, approximately 40% of patients do not …
Lymphatic function in autoimmune diseases
N Schwartz, MLS Chalasani, TM Li, Z Feng… - Frontiers in …, 2019 - frontiersin.org
Lymphatic vessels are critical for clearing fluid and inflammatory cells from inflamed tissues
and also have roles in immune tolerance. Given the functional association of the lymphatics …
and also have roles in immune tolerance. Given the functional association of the lymphatics …
Ex vivo Demonstration of Functional Deficiencies in Popliteal Lymphatic Vessels From TNF-Transgenic Mice With Inflammatory Arthritis
Background: Recent studies demonstrated lymphangiogenesis and expansion of draining
lymph nodes during chronic inflammatory arthritis, and lymphatic dysfunction associated …
lymph nodes during chronic inflammatory arthritis, and lymphatic dysfunction associated …
CCL19‐Positive Lymph Node Stromal Cells Govern the Onset of Inflammatory Arthritis via Tropomyosin Receptor Kinase
F Schälter, V Azizov, M Frech, K Dürholz… - Arthritis & …, 2024 - Wiley Online Library
Objective The study objective was to assess the role of CCL19+ lymph node stromal cells of
the joint‐draining popliteal lymph node (pLN) for the development of arthritis. Methods …
the joint‐draining popliteal lymph node (pLN) for the development of arthritis. Methods …
IL-23 in arthritic and inflammatory pain development in mice
Abstract Background The cytokine, interleukin-23 (IL-23), can be critical for the progression
of inflammatory diseases, including arthritis, and is often associated with T lymphocyte …
of inflammatory diseases, including arthritis, and is often associated with T lymphocyte …
Altered lymphatic vessel anatomy and markedly diminished lymph clearance in affected hands of patients with active rheumatoid arthritis
Objective To assess differences between lymphatic function in the affected hands of
rheumatoid arthritis (RA) patients with active synovitis and that of healthy controls, using …
rheumatoid arthritis (RA) patients with active synovitis and that of healthy controls, using …
[HTML][HTML] Preliminary test of Polish translation of the Rheumatoid and Arthritis Outcome Score–observational study
Ł Pulik, A Zalewski, N Dyrek, W Skała, P Łęgosz - Reumatologia, 2024 - ncbi.nlm.nih.gov
Results The translation, adaptation, and pre-test of the Polish RAOS resulted in the final
version of the scale, which can be found in Supplementary material 1. Conclusions During …
version of the scale, which can be found in Supplementary material 1. Conclusions During …
Axillary lymph-node metabolic activity assessment on 18F-FDG-PET/CT in rheumatoid arthritis patients treated with biologic therapies
TT Dam, K Okamura, T Nakajima… - Scandinavian Journal …, 2020 - Taylor & Francis
Objective: Recent studies have provided new insights into the role of lymph nodes (LNs) in
rheumatoid arthritis (RA). The aim of this study was to evaluate the metabolic activity of the …
rheumatoid arthritis (RA). The aim of this study was to evaluate the metabolic activity of the …
Near-Infrared Imaging of Indocyanine Green Identifies Novel Routes of Lymphatic Drainage from Metacarpophalangeal Joints in Healthy Human Hands
Background: Collecting lymphatic vessel (CLV) dysfunction has been implicated in various
diseases, including rheumatoid arthritis (RA). RA patients with active hand arthritis exhibit …
diseases, including rheumatoid arthritis (RA). RA patients with active hand arthritis exhibit …
[PDF][PDF] THE LYMPHOSOME CONCEPT AND UNEXPECTED LYMPHATIC DRAINAGE
The lymphatic system includes an extensive network of vessels deputed to the drainage of
extravasated fluids. The system is responsible for tissue fluid homeostasis, lipid absorption …
extravasated fluids. The system is responsible for tissue fluid homeostasis, lipid absorption …