Targeting lymphatic function as a novel therapeutic intervention for rheumatoid arthritis

EM Bouta, RD Bell, H Rahimi, L Xing… - Nature Reviews …, 2018 - nature.com
Although clinical outcomes for patients with rheumatoid arthritis (RA) have greatly improved
with the use of biologic and conventional DMARDs, approximately 40% of patients do not …

Lymphatic function in autoimmune diseases

N Schwartz, MLS Chalasani, TM Li, Z Feng… - Frontiers in …, 2019 - frontiersin.org
Lymphatic vessels are critical for clearing fluid and inflammatory cells from inflamed tissues
and also have roles in immune tolerance. Given the functional association of the lymphatics …

Ex vivo Demonstration of Functional Deficiencies in Popliteal Lymphatic Vessels From TNF-Transgenic Mice With Inflammatory Arthritis

JP Scallan, EM Bouta, H Rahimi, HM Kenney… - Frontiers in …, 2021 - frontiersin.org
Background: Recent studies demonstrated lymphangiogenesis and expansion of draining
lymph nodes during chronic inflammatory arthritis, and lymphatic dysfunction associated …

CCL19‐Positive Lymph Node Stromal Cells Govern the Onset of Inflammatory Arthritis via Tropomyosin Receptor Kinase

F Schälter, V Azizov, M Frech, K Dürholz… - Arthritis & …, 2024 - Wiley Online Library
Objective The study objective was to assess the role of CCL19+ lymph node stromal cells of
the joint‐draining popliteal lymph node (pLN) for the development of arthritis. Methods …

IL-23 in arthritic and inflammatory pain development in mice

KMC Lee, Z Zhang, A Achuthan, AJ Fleetwood… - Arthritis research & …, 2020 - Springer
Abstract Background The cytokine, interleukin-23 (IL-23), can be critical for the progression
of inflammatory diseases, including arthritis, and is often associated with T lymphocyte …

Altered lymphatic vessel anatomy and markedly diminished lymph clearance in affected hands of patients with active rheumatoid arthritis

RD Bell, H Rahimi, HM Kenney… - Arthritis & …, 2020 - Wiley Online Library
Objective To assess differences between lymphatic function in the affected hands of
rheumatoid arthritis (RA) patients with active synovitis and that of healthy controls, using …

[HTML][HTML] Preliminary test of Polish translation of the Rheumatoid and Arthritis Outcome Score–observational study

Ł Pulik, A Zalewski, N Dyrek, W Skała, P Łęgosz - Reumatologia, 2024 - ncbi.nlm.nih.gov
Results The translation, adaptation, and pre-test of the Polish RAOS resulted in the final
version of the scale, which can be found in Supplementary material 1. Conclusions During …

Axillary lymph-node metabolic activity assessment on 18F-FDG-PET/CT in rheumatoid arthritis patients treated with biologic therapies

TT Dam, K Okamura, T Nakajima… - Scandinavian Journal …, 2020 - Taylor & Francis
Objective: Recent studies have provided new insights into the role of lymph nodes (LNs) in
rheumatoid arthritis (RA). The aim of this study was to evaluate the metabolic activity of the …

Near-Infrared Imaging of Indocyanine Green Identifies Novel Routes of Lymphatic Drainage from Metacarpophalangeal Joints in Healthy Human Hands

HM Kenney, G Dieudonne, S Yee, JH Maki… - Lymphatic Research …, 2023 - liebertpub.com
Background: Collecting lymphatic vessel (CLV) dysfunction has been implicated in various
diseases, including rheumatoid arthritis (RA). RA patients with active hand arthritis exhibit …

[PDF][PDF] THE LYMPHOSOME CONCEPT AND UNEXPECTED LYMPHATIC DRAINAGE

F YAPRAK, İ ÇOBAN - Prof. Dr. Bedriye Tunçsiper Prof. Dr. Berna Dirim … - researchgate.net
The lymphatic system includes an extensive network of vessels deputed to the drainage of
extravasated fluids. The system is responsible for tissue fluid homeostasis, lipid absorption …