This report is an overview of the current state of the science relative to environmental
endocrine disruption in humans, laboratory testing, and wildlife species. Background …

Currently used rodent tumor models, including transgenictumor models, or subcutaneously-
growing human tumors inimmunodeficient mice, do not sufficiently represent clinicalcancer …

MYCN amplification and overexpression are common in neuroendocrine prostate cancer
(NEPC). However, the impact of aberrant N-Myc expression in prostate tumorigenesis and …

New incidence of prostate cancer is a major public health issue in the Western world, and
has been rising in other areas of the globe in recent years. In an effort to understanding the …

Since the NF-κB/relA transcription factor is constitutively activated in human prostate cancer
cells, we determined whether blocking NF-κB/relA activity in human prostate cancer cells …

Rapid evaluation of new cytotoxic agents and biological response modifiers for therapy of
cancer and elucidation of their mechanisms of action require the use of relevant animal …

The process of cancer metastasis is sequential and selective and contains stochastic
elements. The growth of metastases represents the endpoint of many lethal events that few …

We have previously described a small interfering RNA (siRNA) delivery system (AtuPLEX)
for RNA interference (RNAi) in the vasculature of mice. Here we report preclinical data for …

Several drugs approved for a variety of indications have been shown to exhibit
antiangiogenic effects. Our study focuses on the PPARγ ligand rosiglitazone, a compound …

BACKGROUND Clinically, the lethal phenotypes of human prostate cancer are
characterized by their progression to androgen‐independence and their propensity to form …