Oxidative stress and inflammation are two critical pathological processes of cerebral
ischemia-reperfusion injury. Myeloperoxidase (MPO) is a critical inflammatory enzyme and …

Transient or permanent interruption of cerebral blood flow by occlusion of a cerebral artery
gives rise to an ischaemic stroke leading to irreversible damage or dysfunction to the cells …

Inflammation is an innate immune response to infection or tissue damage that is designed to
limit harm to the host, but contributes significantly to ischemic brain injury following stroke …

Abstract Glucagon-like peptide-1 (GLP-1) is an incretin hormone that increases glucose-
dependent insulin secretion to reduce the glucose level. Liraglutide, a long-acting GLP-1 …

Neuroprotection aims to prevent salvageable neurons from dying. Despite showing efficacy
in experimental stroke studies, the concept of neuroprotection has failed in clinical trials …

While numerous lines of evidence point to increased levels of oxidative stress playing a
causal role in a number of neurodegenerative conditions, our current understanding of the …

Ischemic stroke accounts for nearly 80% of stroke cases. Recanalization with thrombolysis is
a currently crucial therapeutic strategy for re-building blood supply, but the thrombolytic …

Oligodendrocytes (OL s), the myelin‐forming cells of the central nervous system, form a
functional unit with axons and play a crucial role in axonal integrity. An episode of hypoxia …

It has been proven that physical exercise improves cognitive function and memory, has an
analgesic and antidepressant effect, and delays the aging of the brain and the development …

Background: Stroke is one of the major challenges to health and the reason for increasing
disability-adjusted life years. Despite tremendous progress in preclinical studies, none of the …