Notch signaling pathway: architecture, disease, and therapeutics

B Zhou, W Lin, Y Long, Y Yang, H Zhang… - Signal transduction and …, 2022 - nature.com
The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

A guide to the composition and functions of the extracellular matrix

NK Karamanos, AD Theocharis, Z Piperigkou… - The FEBS …, 2021 - Wiley Online Library
Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Therapeutic targets in lung tissue remodelling and fibrosis

G Liu, AM Philp, T Corte, MA Travis, H Schilter… - Pharmacology & …, 2021 - Elsevier
Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …

Staphylococcus aureus Toxins and Their Molecular Activity in Infectious Diseases

D Oliveira, A Borges, M Simões - Toxins, 2018 - mdpi.com
Staphylococcus aureus is a microorganism resident in the skin and nasal membranes with a
dreadful pathogenic potential to cause a variety of community and hospital-acquired …

Extracellular matrix structure

AD Theocharis, SS Skandalis, C Gialeli… - Advanced drug delivery …, 2016 - Elsevier
Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network
composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins …

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family

R Kelwick, I Desanlis, GN Wheeler, DR Edwards - Genome biology, 2015 - Springer
Abstract The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs)
enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that …

Is there new hope for therapeutic matrix metalloproteinase inhibition?

RE Vandenbroucke, C Libert - Nature reviews Drug discovery, 2014 - nature.com
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that form a family of
24 members in mammals. Evidence of the pathological roles of MMPs in various diseases …

Targeting metalloenzymes for therapeutic intervention

AY Chen, RN Adamek, BL Dick, CV Credille… - Chemical …, 2018 - ACS Publications
Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

[HTML][HTML] The pro-and anti-inflammatory properties of the cytokine interleukin-6

J Scheller, A Chalaris, D Schmidt-Arras… - Biochimica et Biophysica …, 2011 - Elsevier
Interleukin-6 is a cytokine not only involved in inflammation and infection responses but also
in the regulation of metabolic, regenerative, and neural processes. In classic signaling …

Matrix metalloproteinases: regulators of the tumor microenvironment

K Kessenbrock, V Plaks, Z Werb - Cell, 2010 - cell.com
Extracellular proteolysis mediates tissue homeostasis. In cancer, altered proteolysis leads to
unregulated tumor growth, tissue remodeling, inflammation, tissue invasion, and metastasis …