Axonal regeneration: underlying molecular mechanisms and potential therapeutic targets

R Akram, H Anwar, MS Javed, A Rasul, A Imran… - Biomedicines, 2022 - mdpi.com
Axons in the peripheral nervous system have the ability to repair themselves after damage,
whereas axons in the central nervous system are unable to do so. A common and important …

[HTML][HTML] Novel multi-drug delivery hydrogel using scar-homing liposomes improves spinal cord injury repair

Q Wang, H Zhang, H Xu, Y Zhao, Z Li, J Li, H Wang… - Theranostics, 2018 - ncbi.nlm.nih.gov
Proper selection and effective delivery of combination drugs targeting multiple
pathophysiological pathways key to spinal cord injury (SCI) hold promise to address the thus …

[PDF][PDF] Systematic analysis of purified astrocytes after SCI unveils Zeb2os function during astrogliosis

H Wei, X Wu, Y You, RCD Duran, Y Zheng… - Cell reports, 2021 - cell.com
Spinal cord injury (SCI) is one of the most devastating neural injuries without effective
therapeutic solutions. Astrocytes are the predominant component of the scar. Understanding …

UTX/KDM6A deletion promotes the recovery of spinal cord injury by epigenetically triggering intrinsic neural regeneration

Z Guo, C Li, Y Cao, T Qin, L Jiang, Y Xu, M Li… - … Therapy-Methods & …, 2021 - cell.com
Interrupted axons that fail to regenerate mainly cause poor recovery after spinal cord injury
(SCI). How neurons epigenetically respond to injury determines the intrinsic growth ability of …

Serum concentrations of fibrinogen in patients with spinal cord injury and its relationship with neurologic function

JM Liu, M Lan, Y Zhou, XY Chen, SH Huang, ZL Liu - World Neurosurgery, 2017 - Elsevier
Background Many studies have focused on axon regeneration after spinal cord injury (SCI),
and fibrinogen has been reported to be an inhibitory factor for axon regeneration. However …

Combined Gene Therapy and Rehabilitative Approaches to Repair the Corticospinal Tract Following Injury

A Kramer - 2021 - search.proquest.com
Spinal cord injury (SCI) is a condition that has plagued humans for centuries, and still there
is no effective treatment to restore neuronal deficits caused by trauma. Unlike the peripheral …

[图书][B] Tissue engineering and pharmacological approaches for the treatment of spinal cord injuries

M Farrag - 2020 - search.proquest.com
Abstract The World Health Organization (WHO) estimated the number of spinal cord injuries
to be between 250,000 and 500,000 new cases every year, with an increasing incidence …