Recent advances in our understanding of the structure-function relationship of motile cilia
with the 9+ 2 microtubular arrangement have helped explain some of the mechanisms of …

Background Cilia are complex and powerful cellular structures of the respiratory mucosa that
play a critical role in airway defense. Respiratory epithelium is lined with cilia that perform an …

One of the main functions of the airway epithelium is to inactivate and remove infectious
particles from inhaled air and thereby prevent infection of the distal lung. This function is …

Chronic rhinosinusitis (CRS), affecting more than 35 million Americans of all ages, 1
represents several distinct entities which are clinically indistinguishable. Although the …

To determine whether induced metabolic alkalosis affects sweat composition, 10 males
cycled for 90 min at 62.5±1.3% peak oxygen uptake, on two separate occasions. Subjects …

Background & Aims: Cholinergic stimulation of chloride secretion is impaired in the
intestines of patients with cystic fibrosis (CF). However, intestinal chloride secretion has …

pHi affects a number of cellular functions, but the influence of pHi on mammalian ciliary beat
frequency (CBF) is not known. CBF and pHi of single human tracheobronchial epithelial …

Cilia are a ubiquitous organelle found on diverse cell types including sperm cells of
vertebrates and some invertebrates, unicellular protozoa, and several vertebrate epithelial …

In cystic fibrosis (CF), dysfunction of the cystic fibrosis transmembrane conductance
regulator (CFTR) Cl− channel disrupts epithelial ion transport and perturbs the regulation of …

Cystic fibrosis (CF) is an autosomal recessive disease caused by CFTR mutations. It is
characterized by high NaCl concentration in sweat and the production of a thick and sticky …