[HTML][HTML] Wnt and PI3K/Akt/mTOR survival pathways as therapeutic targets in glioblastoma

A Barzegar Behrooz, Z Talaie, F Jusheghani… - International journal of …, 2022 - mdpi.com
Glioblastoma (GBM) is a devastating type of brain tumor, and current therapeutic treatments,
including surgery, chemotherapy, and radiation, are palliative at best. The design of effective …

Frontiers in the treatment of glioblastoma: Past, present and emerging

TI Janjua, P Rewatkar, A Ahmed-Cox, I Saeed… - Advanced drug delivery …, 2021 - Elsevier
Glioblastoma (GBM) is one of the most aggressive cancers of the brain. Despite extensive
research over the last several decades, the survival rates for GBM have not improved and …

[HTML][HTML] The research progress of antiangiogenic therapy, immune therapy and tumor microenvironment

H Hu, Y Chen, S Tan, S Wu, Y Huang, S Fu… - Frontiers in …, 2022 - frontiersin.org
Anti-angiogenesis therapy, a promising strategy against cancer progression, is limited by
drug-resistance, which could be attributed to changes within the tumor microenvironment …

[HTML][HTML] Hypoxia: the cornerstone of glioblastoma

M Domènech, A Hernández, A Plaja… - International journal of …, 2021 - mdpi.com
Glioblastoma is the most aggressive form of brain tumor in adults and is characterized by the
presence of hypervascularization and necrosis, both caused by a hypoxic …

[HTML][HTML] Exosome-based nanoimmunotherapy targeting TAMs, a promising strategy for glioma

H Luo, H Zhang, J Mao, H Cao, Y Tao, G Zhao… - Cell Death & …, 2023 - nature.com
Exosomes, the cell-derived small extracellular vehicles, play a vital role in intracellular
communication by reciprocally transporting DNA, RNA, bioactive protein, chains of glucose …

[HTML][HTML] Tumor-associated microglia and macrophages in the glioblastoma microenvironment and their implications for therapy

RS Andersen, A Anand, DSL Harwood, BW Kristensen - Cancers, 2021 - mdpi.com
Simple Summary Patients with glioblastoma—the most frequent and malignant primary brain
tumor—have a poor prognosis with a median survival of less than 15 months. Despite …

Unraveling the Plasma Protein Corona by Ultrasonic Cavitation Augments Active‐Transporting of Liposome in Solid Tumor

G Wang, Y Jiang, J Xu, J Shen, T Lin, J Chen… - Advanced …, 2023 - Wiley Online Library
Ligand/receptor‐mediated targeted drug delivery has been widely recognized as a
promising strategy for improving the clinical efficacy of nanomedicines but is attenuated by …

The landscape of biomimetic nanovesicles in brain diseases

Q You, F Liang, G Wu, F Cao, J Liu, Z He… - Advanced …, 2024 - Wiley Online Library
Brain diseases, such as brain tumors, neurodegenerative diseases, cerebrovascular
diseases, and brain injuries, are caused by various pathophysiological changes, which pose …

[HTML][HTML] New directions in the therapy of glioblastoma

K Szklener, M Mazurek, M Wieteska, M Wacławska… - Cancers, 2022 - mdpi.com
Simple Summary Despite the continuous development of treatment technology,
glioblastoma remains a challenge for modern medicine. The standard of care remains a …

[HTML][HTML] Macrophages in recurrent glioblastoma as a prognostic factor in the synergistic system of the tumor microenvironment

N Montemurro, B Pahwa, A Tayal, A Shukla… - Neurology …, 2023 - mdpi.com
Glioblastoma (GBM) is a common and highly malignant primary tumor of the central nervous
system in adults. Ever more recent papers are focusing on understanding the role of the …