Development of new tuberculosis drugs: translation to regimen composition for drug-sensitive and multidrug-resistant tuberculosis
Tuberculosis (TB) kills more people than any other infectious disease. Challenges for
developing better treatments include the complex pathology due to within-host immune …
developing better treatments include the complex pathology due to within-host immune …
Global sensitivity analysis of biological multiscale models
M Renardy, C Hult, S Evans, JJ Linderman… - Current opinion in …, 2019 - Elsevier
Mathematical models of biological systems need to both reflect and manage the inherent
complexities of biological phenomena. Through their versatility and ability to capture …
complexities of biological phenomena. Through their versatility and ability to capture …
Cumulative human health risk analysis of trihalomethanes exposure in drinking water systems
Chlorinated compounds on reaction with natural organic substances present in water leads
to the formation of trihalomethanes (THMs), a major type of disinfection by-products (DBPs) …
to the formation of trihalomethanes (THMs), a major type of disinfection by-products (DBPs) …
[HTML][HTML] Both pharmacokinetic variability and granuloma heterogeneity impact the ability of the first-line antibiotics to sterilize tuberculosis granulomas
JM Cicchese, V Dartois, DE Kirschner… - Frontiers in …, 2020 - frontiersin.org
Tuberculosis (TB) remains as one of the world's deadliest infectious diseases despite the
use of standardized antibiotic therapies. Recommended therapy for drug-susceptible TB is …
use of standardized antibiotic therapies. Recommended therapy for drug-susceptible TB is …
[HTML][HTML] A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination
Mycobacterium tuberculosis (Mtb), the causative infectious agent of tuberculosis (TB), kills
more individuals per year than any other infectious agent. Granulomas, the hallmark of Mtb …
more individuals per year than any other infectious agent. Granulomas, the hallmark of Mtb …
[HTML][HTML] A multi-scale pipeline linking drug transcriptomics with pharmacokinetics predicts in vivo interactions of tuberculosis drugs
JM Cicchese, A Sambarey, D Kirschner… - Scientific Reports, 2021 - nature.com
Tuberculosis (TB) is the deadliest infectious disease worldwide. The design of new
treatments for TB is hindered by the large number of candidate drugs, drug combinations …
treatments for TB is hindered by the large number of candidate drugs, drug combinations …
[HTML][HTML] A Credibility Assessment Plan for an In Silico Model that Predicts the Dose–Response Relationship of New Tuberculosis Treatments
C Curreli, V Di Salvatore, G Russo… - Annals of Biomedical …, 2023 - Springer
Tuberculosis is one of the leading causes of death in several developing countries and a
public health emergency of international concern. In Silico Trials can be used to support …
public health emergency of international concern. In Silico Trials can be used to support …
[HTML][HTML] Mathematical models of drug-resistant tuberculosis lack bacterial heterogeneity: A systematic review
NM Fuller, CF McQuaid, MJ Harker… - Plos …, 2024 - journals.plos.org
Drug-resistant tuberculosis (DR-TB) threatens progress in the control of TB. Mathematical
models are increasingly being used to guide public health decisions on managing both …
models are increasingly being used to guide public health decisions on managing both …
Pulmonary delivery of linezolid nanoparticles for treatment of tuberculosis: design, development, and optimization
S Shah, H Maheshwari, M Soniwala… - Journal of Pharmaceutical …, 2022 - Springer
Purpose The present study was aimed to develop and optimize linezolid loaded chitosan
nanoparticles for pulmonary delivery. The objective was to achieve the mean particle size of …
nanoparticles for pulmonary delivery. The objective was to achieve the mean particle size of …
A systematic efficacy analysis of tuberculosis treatment with BPaL‐containing regimens using a multiscale modeling approach
Tuberculosis (TB) is a life‐threatening infectious disease. The standard treatment is up to
90% effective; however, it requires the administration of four antibiotics (isoniazid, rifampicin …
90% effective; however, it requires the administration of four antibiotics (isoniazid, rifampicin …