Diagnostic, prognostic, and mechanistic biomarkers of diabetes mellitus-associated cognitive decline

H Ehtewish, A Arredouani, O El-Agnaf - International journal of molecular …, 2022 - mdpi.com
Cognitive dysfunctions such as mild cognitive impairment (MCI), Alzheimer's disease (AD),
and other forms of dementia are recognized as common comorbidities of type 2 diabetes …

Brain alarm by self-extracellular nucleic acids: From neuroinflammation to neurodegeneration

R Kunze, S Fischer, HH Marti, KT Preissner - Journal of Biomedical …, 2023 - Springer
Neurological disorders such as stroke, multiple sclerosis, as well as the neurodegenerative
diseases Parkinson's or Alzheimer's disease are accompanied or even powered by danger …

Common diseases alter the physiological age-related blood microRNA profile

T Fehlmann, B Lehallier, N Schaum, O Hahn… - Nature …, 2020 - nature.com
Aging is a key risk factor for chronic diseases of the elderly. MicroRNAs regulate post-
transcriptional gene silencing through base-pair binding on their target mRNAs. We …

A microRNA signature that correlates with cognition and is a target against cognitive decline

MR Islam, L Kaurani, T Berulava… - EMBO molecular …, 2021 - embopress.org
While some individuals age without pathological memory impairments, others develop age‐
associated cognitive diseases. Since changes in cognitive function develop slowly over time …

Alzheimer's disease and microRNA-132: a widespread pathological factor and potential therapeutic target

M Zhang, Z Bian - Frontiers in Neuroscience, 2021 - frontiersin.org
Alzheimer's disease (AD) is a common neurodegenerative disease in the elderly and is the
most common type of dementia. AD is mostly gradual onset, and involves slow, progressive …

Analysis of serum miRNAs in Alzheimer's disease

L Lu, WZ Dai, XC Zhu, T Ma - American Journal of …, 2021 - journals.sagepub.com
This paper was aimed to analyze the microRNA (miRNA) signatures in Alzheimer disease
(AD) and find the significant expressions of miRNAs, their target genes, the functional …

MicroRNA 146a is associated with diabetic complications in type 1 diabetic patients from the EURODIAB PCS

F Barutta, B Corbetta, S Bellini, S Guarrera… - Journal of translational …, 2021 - Springer
Abstract Background MicroRNA-146a-5p (miR-146a-5p) is a key regulator of inflammatory
processes. Expression of miR-146a-5p is altered in target organs of diabetic complications …

Circulating inflamma-miRs as potential biomarkers of cognitive impairment in patients affected by Alzheimer's disease

A Giuliani, S Gaetani, G Sorgentoni… - Frontiers in aging …, 2021 - frontiersin.org
Alzheimer's disease (AD), the most prevalent neurodegenerative disease in the growing
population of elderly people, is still lacking minimally-invasive circulating biomarkers that …

The impact of melatonin and NLRP3 inflammasome on the expression of microRNAs in aged muscle

RKA Sayed, M Fernández-Ortiz, J Fernández-Martínez… - Antioxidants, 2021 - mdpi.com
Muscular aging is a complex process and underlying physiological mechanisms are not fully
clear. In recent years, the participation of the NF-kB pathway and the NLRP3 inflammasome …

MicroRNAs as candidate biomarkers for Alzheimer's disease

C Kanach, JK Blusztajn, A Fischer, I Delalle - Non-coding RNA, 2021 - mdpi.com
The neurological damage of Alzheimer's disease (AD) is thought to be irreversible upon
onset of dementia-like symptoms, as it takes years to decades for occult pathologic changes …