Stress is viewed as a state of real or perceived threat to homeostasis, the management of
which involves the endocrine, nervous, and immune systems. These systems work …

TDP-43 is an RNA-binding protein with a crucial nuclear role in splicing, and mislocalises
from the nucleus to the cytoplasm in a range of neurodegenerative disorders. TDP-43 …

BACKGROUND The mammalian immune system is a remarkable sensory system for the
detection and neutralization of pathogens. History is replete with the devastating effects of …

One lead genetic risk signal of obesity—the rs1421085 T> C variant within the FTO gene—is
reported to be functional in vitro but lacks evidence at an organism level. Here we …

Amyotrophic lateral sclerosis is a complex disorder most of which is 'sporadic'of unknown
origin but approximately 10% is familial, arising from single mutations in any of more than 30 …

Current influenza vaccines predominantly induce immunity to the hypervariable
hemagglutinin (HA) head, requiring frequent vaccine reformulation. Conversely, the …

The dense network of interconnected cellular signalling responses that are quantifiable in
peripheral immune cells provides a wealth of actionable immunological insights. Although …

Background: Epidemiological data link traffic-related air pollution (TRAP) to increased risk of
Alzheimer's disease (AD). Preclinical data corroborating this association are largely from …

Neurodegenerative diseases (NDs) are characterized by uncontrolled loss of neuronal cells
leading to a progressive deterioration of brain functions. The transition rate of numerous …

Oncology immunotherapy has been a significant advancement in cancer treatment and
involves harnessing and redirecting a patient's immune response towards their own tumour …