Background Melatonin, a well-known antioxidant, has been shown to possess anti-invasive
properties for glioma. However, little is known about the effect of melatonin on glioma cell …

The anti-diabetic drug, metformin, exerts its action through AMP-activated protein kinase
(AMPK), and Sirtuin (Sirt1) signaling. Insulin-like growth factor (IGF)-binding protein 2 …

Atmospheric pressure cold plasma showed selective killing efficiency on cancer cells in vitro
and in vivo, which makes plasma a potential option for cancer therapy. However, the plasma …

Docosahexaenoic acid (DHA) oil is an important polyunsaturated fatty acid for the human
body. Evidence has demonstrated that DHA is beneficial for inhibiting mammary …

Morphological changes in mitochondria have been primarily attributed to fission and fusion,
while the more pliable transformations of mitochondria (remodeling, rounding, or stretching) …

Tumor cells show metabolic features distinctive from normal tissues, with characteristically
enhanced aerobic glycolysis, glutaminolysis and lipid synthesis. Peroxisome proliferator …

Statins and non-statin medications used for the management of dyslipidemia have been
shown to possess antitumor properties. Since the use of these drugs has steadily increased …

Fenofibrate, a fibric acid derivative, is known to possess lipid-lowering effects. Although
fenofibrate-induced peroxisome proliferator-activated receptor alpha (PPARα) …

Ketone bodies [beta-hydroxybutyrate (bHB) and acetoacetate] are mainly produced in the
liver during prolonged fasting or starvation. bHB is a very efficient energy substrate for …

Metronomic agents reduce the effective doses and adverse effects of cytostatics in cancer
chemotherapy. Therefore, they can enhance the treatment efficiency of drug-resistant …