Glioma is the most frequent and most malignant tumor of the central nervous system (CNS),
accounting for about 50% of all CNS tumor and approximately 80% of the malignant primary …

Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2), one of the most abundant
circulating IGFBPs, is known to attenuate the biological action of IGF-1. Although the effect of …

Glioblastoma multiforme is characterized by rapid proliferation, aggressive metastatic
potential, and resistance to radio-and chemotherapy. The matricellular protein CYR61 …

Aim: IDH-mutant lower grade glioma (LGG) has been proven to have a good prognosis.
However, its high recurrence rate has become a major therapeutic difficulty. Materials & …

Angiogenesis (blood vessel formation) is essential for tissue growth in both normal
development and physiology and in some diseases such as inflammation and cancer …

Background As per facts sheet of WHO, cancer is a leading cause of mortality worldwide
accounting nearly 10 million deaths in 2020. However, breast, lung, colon and rectum …

Extravasation of circulating cancer cells is regulated by the intercellular/intracellular
signaling pathways that locally impair the endothelial barrier function. Co-cultures of human …

Adjuvant-induced arthritis is a chronic inflammatory illness that induces muscle wasting and
decreases circulating IGF1. Eicosapentaenoic acid (EPA) and fenofibrate, a peroxisome …

Objective: To review the mechanisms of anti-cancer activity of fenofibrate (FF) and other
Peroxisome Proliferator Activator Receptor α (PPARα) agonists based on evidences …

Peroxisome proliferator-activated receptors (PPARs) function as nuclear transcription factors
upon the binding of physiological or pharmacological ligands and heterodimerization with …