The transition between epithelial and mesenchymal phenotype is emerging as a key
determinant of tumor cell invasion and metastasis. It is a plastic process in which epithelial …

Introduction Radiotherapy is a mainstay of cancer treatment. Clinical studies revealed a
heterogenous response to radiotherapy, from a complete response to even disease …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

Metabolic alterations play a key role in promoting tumor initiation and progression, leading
to extensive tumor heterogeneity and adaptability. Thus, targeting abnormal metabolic …

Mitochondria are the cytoplasmic organelles mostly known as the “electric engine” of the
cells; however, they also play pivotal roles in different biological processes, such as cell …

Cancer stem cells (CSCs) are a subset of cancer cells with self-renewal ability and tumor
initiating properties. Unlike the other non-stem cancer cells, CSCs resist traditional therapy …

Chronic metabolic stress paradoxically elicits pro-tumorigenic signals that facilitate cancer
stem cell (CSC) development. Therefore, elucidating the metabolic sensing and signaling …

The excessive generation of reactive oxygen species (ROS) plays a pivotal role in the
pathogenesis of diseases. ROS are central to cellular redox regulation and act as second …

Simple Summary Head and neck squamous cell carcinomas (HNSCC) are common
malignancies with considerable morbidity and a high death toll worldwide. Resistance …

Simple Summary Cancers in the head and neck region are often aggressive and poorly
respond to both irradiation or chemotherapy. Chemotherapy is currently limited by a small …