Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections

Y Zhu, W Hao, X Wang, J Ouyang… - Medicinal Research …, 2022 - Wiley Online Library
Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), are important
effector immune defense molecules in multicellular organisms. AMPs exert their …

The role of reactive species on innate immunity

CMC Andrés, JM Pérez de la Lastra, CA Juan, FJ Plou… - Vaccines, 2022 - mdpi.com
This review examines the role of reactive species RS (of oxygen ROS, nitrogen RNS and
halogen RHS) on innate immunity. The importance of these species in innate immunity was …

Secondary amine pendant β-peptide polymers displaying potent antibacterial activity and promising therapeutic potential in treating MRSA-induced wound infections …

Y Qian, S Deng, Z Cong, H Zhang, Z Lu… - Journal of the …, 2022 - ACS Publications
Interest in developing antibacterial polymers as synthetic mimics of host defense peptides
(HPDs) has accelerated in recent years to combat antibiotic-resistant bacterial infections …

Antimicrobial mechanisms and clinical application prospects of antimicrobial peptides

X Li, S Zuo, B Wang, K Zhang, Y Wang - Molecules, 2022 - mdpi.com
Antimicrobial peptides are a type of small-molecule peptide that widely exist in nature and
are components of the innate immunity of almost all living things. They play an important role …

Light-activated molecular machines are fast-acting broad-spectrum antibacterials that target the membrane

AL Santos, D Liu, AK Reed, AM Wyderka… - Science …, 2022 - science.org
The increasing occurrence of antibiotic-resistant bacteria and the dwindling antibiotic
research and development pipeline have created a pressing global health crisis. Here, we …

Structure–activity relationships of antibacterial peptides

MG Ciulla, F Gelain - Microbial biotechnology, 2023 - Wiley Online Library
Antimicrobial peptides play a crucial role in innate immunity, whose components are mainly
peptide‐based molecules with antibacterial properties. Indeed, the exploration of the …

Novel approaches to combat medical device-associated biofilms

X Li, L Sun, P Zhang, Y Wang - Coatings, 2021 - mdpi.com
Biofilms are aggregates formed as a protective survival state by microorganisms to adapt to
the environment and can be resistant to antimicrobial agents and host immune responses …

[HTML][HTML] An update on antimicrobial peptides (AMPs) and their delivery strategies for wound infections

V Patrulea, G Borchard, O Jordan - Pharmaceutics, 2020 - mdpi.com
Bacterial infections occur when wound healing fails to reach the final stage of healing, which
is usually hindered by the presence of different pathogens. Different topical antimicrobial …

Synthesis and molecular docking study of α-aminophosphonates as potential multi-targeting antibacterial agents

RR Neiber, NA Samak, J Xing, EI Elmongy… - Journal of Hazardous …, 2024 - Elsevier
Antibacterial compounds that reduce extracellular polymeric substances (EPS) are needed
to avoid bacterial biofilms in water pipelines. Herein, green one-pot synthesis of α …

A Novel Antimicrobial Peptide Spampcin56–86 from Scylla paramamosain Exerting Rapid Bactericidal and Anti-Biofilm Activity In Vitro and Anti-Infection In Vivo

M Jiang, R Chen, J Zhang, F Chen… - International Journal of …, 2022 - mdpi.com
The abuse of antibiotics leads to the increase of bacterial resistance, which seriously
threatens human health. Therefore, there is an urgent need to find effective alternatives to …