The innate immune response to lipopolysaccharide is essential for host defense against
Gram-negative bacteria. In response to bacterial infection, the TLR4/MD-2 complex that is …

Bacterial membrane vesicles (BMVs) have emerged as novel and promising platforms for
the development of vaccines and immunotherapeutic strategies against infectious and …

Abstract Outer Membrane Vesicles (OMV) have received increased attention in recent years
as a vaccine platform against bacterial pathogens. OMV from Neisseria meningitidis …

Shigella are gram-negative bacteria that cause severe diarrhea and dysentery. In 2013,
Shigella infections caused an estimated 34,400 deaths in children less than five years old …

Outer Membrane Vesicles (OMVs) are bacterial nanoparticles that are spontaneously
released during growth both in vitro and in vivo by Gram-negative bacteria. They are …

To stop the spread of future epidemics and meet infant vaccination demands in low‐and
middle‐income countries, flexible, rapid and low‐cost vaccine development and …

Helicobacter pylori is a paradigm of chronic bacterial infection and is associated with peptic
ulceration and malignancies. H. pylori uses specific masking mechanisms to avoid …

Introduction: Over the last decades, glycoconjugate vaccines have been proven to be a
successful strategy to prevent infectious diseases. Many diseases remain to be controlled …

Generalized Modules for Membrane Antigens (GMMA) are outer membrane vesicles derived
from Gram-negative bacteria engineered to provide an over-vesiculating phenotype, which …

Recently, we developed a high yield production process for outer membrane particles from
genetically modified bacteria, called Generalized Modules of Membrane Antigens (GMMA) …