The turnover of the RNA molecules is determined by the rates of transcription and RNA
degradation. Several methods have been developed to study RNA turnover since the …

Tracking the expression of RNA in a cell‐specific manner is a major challenge in basic and
disease research. Herein we outline the current state of employing chemical approaches for …

Tissues and organs are composed of diverse cell types, which poses a major challenge for
cell-type-specific profiling of gene expression. Current metabolic labeling methods rely on …

Purification of cell type-specific RNAs remains a significant challenge. One solution involves
biosynthetic tagging of target RNAs. RNA tagging via incorporation of 4-thiouracil (TU) in …

In the context of the COVID-19 pandemic, we describe here the singular metabolic
background that constrains enveloped RNA viruses to evolve toward likely attenuation in the …

Uridine monophosphate (UMP) is a major nucleotide analogue in mammalian milk and
uridine (UR) is its gastro-intestinal metabolite in vivo. This study aims to investigate the …

RNA is a central molecule in numerous cellular processes, including transcription,
translation, and regulation of gene expression. To reveal the numerous facets of RNA …

Dissecting the genetic basis of natural variation in disease response in hosts provides
insights into the coevolutionary dynamics of host-pathogen interactions. Here, a genome …

Orotate phosphoribosyl transferase (OPRTase) plays an important role in de novo and
salvage pathways of nucleotide synthesis and is widely used as a screening marker in …

The blockage of the de novo pyrimidine biosynthetic pathway at the orotidine-5′-phosphate
decarboxylase level was previously demonstrated to affect riboflavin production in the …