Arrhythmogenic cardiomyopathy affects significant number of patients worldwide and is
characterized by life-threatening ventricular arrhythmias and sudden cardiac death …

Epigenetic mechanisms and transcription factor networks essential for differentiation of
cardiac myocytes have been uncovered. However, reshaping of the epigenome of these …

The human transcriptome comprises a complex network of coding and non-coding RNAs
implicated in a myriad of biological functions. Non-coding RNAs exhibit highly organized …

BACKGROUND: The p. Arg14del variant of the PLN (phospholamban) gene causes
cardiomyopathy, leading to severe heart failure. Calcium handling defects and perinuclear …

Rationale: CaMKII (Ca2+-Calmodulin dependent protein kinase) δC activation is implicated
in pathological progression of heart failure (HF) and CaMKIIδC transgenic mice rapidly …

Diabetic cardiomyopathy is defined as the myocardial dysfunction that suffers patients with
diabetes mellitus (DM) in the absence of hypertension and structural heart diseases such as …

Inherited cardiomyopathy caused by the p.(Arg14del) pathogenic variant of the
phospholamban (PLN) gene is characterized by intracardiomyocyte PLN aggregation and …

The nucleus of a cardiomyocyte has been increasingly recognized as a morphologically
distinct and partially independent calcium (Ca2+) signaling microdomain, with its own Ca2+ …

In continuously beating cells like cardiac myocytes, there are rapid alterations of cytosolic
Ca 2+ levels. We therefore hypothesize that decoding Ca 2+ signals for hypertrophic …

Aims Phospholamban (PLB) is the key regulator of the cardiac Ca 2+ pump (SERCA2a)-
mediated sarcoplasmic reticulum Ca 2+ stores. We recently reported that PLB is highly …