[HTML][HTML] Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis
Nanotechnology could improve our understanding of the pathophysiology of atherosclerosis
and contribute to the development of novel diagnostic and therapeutic strategies to further …
and contribute to the development of novel diagnostic and therapeutic strategies to further …
[HTML][HTML] Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities
G Hajishengallis, T Chavakis - Nature Reviews Immunology, 2021 - nature.com
Periodontitis, a major inflammatory disease of the oral mucosa, is epidemiologically
associated with other chronic inflammation-driven disorders, including cardio-metabolic …
associated with other chronic inflammation-driven disorders, including cardio-metabolic …
Macrophage function in adipose tissue homeostasis and metabolic inflammation
Obesity-related metabolic organ inflammation contributes to cardiometabolic disorders. In
obese individuals, changes in lipid fluxes and storage elicit immune responses in the …
obese individuals, changes in lipid fluxes and storage elicit immune responses in the …
[HTML][HTML] Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics
Y Duan, K Gong, S Xu, F Zhang, X Meng… - Signal Transduction and …, 2022 - nature.com
Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …
Cardiovascular considerations for patients, health care workers, and health systems during the COVID-19 pandemic
Abstract The coronavirus disease 2019 (COVID-19) is an infectious disease caused by
severe acute respiratory syndrome coronavirus 2 that has significant implications for the …
severe acute respiratory syndrome coronavirus 2 that has significant implications for the …
[HTML][HTML] Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities
Macrophages, which are key cellular components of the liver, have emerged as essential
players in the maintenance of hepatic homeostasis and in injury and repair processes in …
players in the maintenance of hepatic homeostasis and in injury and repair processes in …
Revisiting the PD-1 pathway
Programmed Death-1 (PD-1; CD279) is an inhibitory receptor induced in activated T cells.
PD-1 engagement by its ligands, PD-L1 and PD-L2, maintains peripheral tolerance but also …
PD-1 engagement by its ligands, PD-L1 and PD-L2, maintains peripheral tolerance but also …
[HTML][HTML] Body localization of ACE-2: on the trail of the keyhole of SARS-CoV-2
F Salamanna, M Maglio, MP Landini, M Fini - Frontiers in medicine, 2020 - frontiersin.org
The explosion of the new coronavirus (SARS-CoV-2) pandemic has brought the role of the
angiotensin converting enzyme 2 (ACE2) back into the scientific limelight. Since SARS-CoV …
angiotensin converting enzyme 2 (ACE2) back into the scientific limelight. Since SARS-CoV …
[HTML][HTML] How location and cellular signaling combine to activate the NLRP3 inflammasome
A Akbal, A Dernst, M Lovotti, MSJ Mangan… - Cellular & molecular …, 2022 - nature.com
Abstract NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune
sensor of cellular stress signals, triggered by infection and sterile inflammation. Upon …
sensor of cellular stress signals, triggered by infection and sterile inflammation. Upon …
High thrombus burden in patients with COVID-19 presenting with ST-segment elevation myocardial infarction
FA Choudry, SM Hamshere, KS Rathod… - Journal of the American …, 2020 - jacc.org
Abstract Background Coronavirus disease-2019 (COVID-19) is thought to predispose
patients to thrombotic disease. To date there are few reports of ST-segment elevation …
patients to thrombotic disease. To date there are few reports of ST-segment elevation …