Accumulation and turnover of extracellular matrix components are the hallmarks of tissue
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety …

Pulmonary fibrosis occurs in a variety of clinical settings, constitutes a major cause of
morbidity and mortality, and represents an enormous unmet medical need. However, the …

Pathological remodeling of the extracellular matrix (ECM) by fibroblasts leads to organ
failure. Development of idiopathic pulmonary fibrosis (IPF) is characterized by a progressive …

The accumulation of a large number of myofibroblasts is responsible for exaggerated and
uncontrolled production of extracellular matrix during the development and progression of …

Accumulation and turnover of extracellular matrix is a hallmark of tissue injury, repair and
remodeling in human diseases. Hyaluronan is a major component of the extracellular matrix …

The fibrotic diseases encompass a wide spectrum of entities including such multisystemic
diseases as systemic sclerosis, nephrogenic systemic fibrosis and sclerodermatous graft …

The WNT family of signaling proteins is essential to organ development in general and lung
morphogenesis in particular. Originally identified as a developmentally active signaling …

Fibrotic interstitial lung diseases are illnesses of unknown cause characterized by
progressive decline in lung function. Fibrocytes are bone marrow-derived, circulating …

Fibrosis, apoptosis, and the exaggerated production of transforming growth factor (TGF)-β 1
are juxtaposed in a variety of pulmonary diseases including the interstitial lung diseases and …

Pulmonary fibrosis is a progressive, dysregulated response to injury culminating in
compromised lung function due to excess extracellular matrix production. The heparan …