The early window of human embryogenesis is largely a black box for developmental
biologists. Here we probed the cellular diversity of 4–6 week human embryos when …

Congenital heart defects (CHDs) are the most common form of birth defects in humans. They
occur in 9 out of 1000 live births and are defined as structural abnormalities of the heart …

Congenital heart disease (CHD) is the leading cause of birth defect‐related death in infants
and is a global pediatric health concern. While the genetic causes of CHD have become …

Aims Retinoic acid (RA) signalling is essential for heart development, and dysregulation of
the RA signalling can cause several types of cardiac outflow tract (OFT) defects, the most …

Background In nonsyndromic conotruncal cardiac defects, the use of next‐generation
sequencing for clinical diagnosis is increasingly adopted, but gene‐disease associations in …

Background: The outflow tract of crocodilians resembles that of birds and mammals as
ventricular septation is complete. The arterial anatomy, however, presents with a pulmonary …

Ciliopathies are associated with wide spectrum of structural birth defects (SBDs), indicating
important roles for cilia in development. Here, we provide novel insights into the …

Background The relationships between maternal genetic and environmental exposure and
conotruncal heart defects (CTDs) have been extensively investigated. Nevertheless, there is …

Background Heart failure due to myocardial infarction (MI) involves fibrosis driven by
epicardium‐derived cells (EPDCs) and cardiac fibroblasts, but strategies to inhibit and …

Conotruncal anomalies, also referred to as outflow tract anomalies, are congenital heart
defects that result from abnormal septation of the great vessels' outflow tracts. The major …