[HTML][HTML] The genetic basis of childhood obesity: A systematic review

A Vourdoumpa, G Paltoglou, E Charmandari - Nutrients, 2023 - mdpi.com
Overweight and obesity in childhood and adolescence represents one of the most
challenging public health problems of our century owing to its epidemic proportions and the …

The neuroscience of sugars in taste, gut-reward, feeding circuits, and obesity

R Gutierrez, E Fonseca, SA Simon - Cellular and Molecular Life Sciences, 2020 - Springer
Throughout the animal kingdom sucrose is one of the most palatable and preferred tastants.
From an evolutionary perspective, this is not surprising as it is a primary source of energy …

[HTML][HTML] Liraglutide restores impaired associative learning in individuals with obesity

R Hanssen, L Rigoux, B Kuzmanovic, S Iglesias… - Nature …, 2023 - nature.com
Survival under selective pressure is driven by the ability of our brain to use sensory
information to our advantage to control physiological needs. To that end, neural circuits …

High-fat food biases hypothalamic and mesolimbic expression of consummatory drives

CM Mazzone, J Liang-Guallpa, C Li, NS Wolcott… - Nature …, 2020 - nature.com
Maintaining healthy body weight is increasingly difficult in our obesogenic environment.
Dieting efforts are often overpowered by the internal drive to consume energy-dense foods …

[HTML][HTML] Large-scale GWAS of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits

S May-Wilson, N Matoba, KH Wade… - Nature …, 2022 - nature.com
We present the results of a GWAS of food liking conducted on 161,625 participants from the
UK-Biobank. Liking was assessed over 139 specific foods using a 9-point scale. Genetic …

[HTML][HTML] Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding

DJ Christoffel, JJ Walsh, BD Heifets, P Hoerbelt… - Nature …, 2021 - nature.com
Hedonic feeding is driven by the “pleasure” derived from consuming palatable food and
occurs in the absence of metabolic need. It plays a critical role in the excessive feeding that …

Ultra-processed foods and binge eating: A retrospective observational study

A Ayton, A Ibrahim, J Dugan, E Galvin, OW Wright - Nutrition, 2021 - Elsevier
Objectives There is increasing evidence of the impact of ultra-processed foods on multiple
metabolic and neurobiological pathways, including those involved in eating behaviors, both …

[HTML][HTML] Dietary sugar inhibits satiation by decreasing the central processing of sweet taste

CE May, J Rosander, J Gottfried, E Dennis, M Dus - Elife, 2020 - elifesciences.org
From humans to vinegar flies, exposure to diets rich in sugar and fat lowers taste sensation,
changes food choices, and promotes feeding. However, how these peripheral alterations …

Brain regulation of hunger and motivation: The case for integrating homeostatic and hedonic concepts and its implications for obesity and addiction

I Morales - Appetite, 2022 - Elsevier
Obesity and other eating disorders are marked by dysregulations to brain metabolic,
hedonic, motivational, and sensory systems that control food intake. Classic approaches in …

[HTML][HTML] Food memory circuits regulate eating and energy balance

TR Pardo-Garcia, K Gu, RKR Woerner, M Dus - Current Biology, 2023 - cell.com
In mammals, learning circuits play an essential role in energy balance by creating
associations between sensory cues and the rewarding qualities of food. This process is …