Early adolescent substance use dramatically increases the risk of lifelong substance use
disorder (SUD). An adolescent sensitive period evolved to allow the development of risk …

It was suggested in 1986 that cue-induced cocaine craving increases progressively during
early abstinence and remains high during extended periods of time. Clinical evidence now …

Adolescents are at increased risk to develop substance use disorders and suffer from
relapse throughout life. Targeted weakening of drug-associated memories has been shown …

Drug addiction is a devastating disorder with a huge economic and social burden for
modern society. Although an individual may slip into drug abuse throughout his/her life …

Rationale Drug use during adolescence results in a life-long risk to develop substance-use
disorders. Adolescent rats are sensitive to different drug-associated cues, compared to …

Adolescent cocaine abuse increases the risk for developing addiction in later life, but the
underlying molecular mechanism remains poorly understood. Here, we establish adolescent …

In individuals with substance use disorders, stress is a critical determinant of relapse
susceptibility. In some cases, stressors directly trigger cocaine use. In others, stressors …

Methamphetamine (METH) is a psychostimulant drug that has become increasingly popular
in recent years, with overdose deaths more than doubling during the second half of the …

Previous studies have shown that adolescent exposure to cocaine increases drug use in
adulthood, albeit incubation of cocaine seeking was found to be attenuated in rats trained to …

Adolescence is a period of significant brain plasticity that can be affected by environmental
factors, including the degree of physical activity. Here we hypothesized that adolescent rats …