Hyperplastic polyps (HPs) of the colon and rectum were historically thought not to be
associated with an increased risk of development of colorectal cancer (CRC). The …

The range of lesions with a serrated appearance within the large intestine has expanded
and become more complex over the last 30 years. The majority of these were previously …

BRAFV600E confers poor prognosis and is associated with a distinct subtype of colorectal
cancer (CRC). Little is known, however, about the genetic events driving the initiation and …

Background RSPO fusions that lead to WNT pathway activation are potential therapeutic
targets in colorectal cancer (CRC), but their clinicopathological significance remains …

(1) Colorectal cancer (CRC) is a leading cause of cancer-related deaths globally. Cancer-
associated fibroblasts (CAFs) are major components of CRC's tumour microenvironment …

Aims RNF43 is suggested to be involved in the serrated pathway towards colorectal cancer
and encodes a transmembrane Ring‐type E3 ubiquitin ligase that negatively regulates the …

Simple Summary Colorectal cancers (CRC) initiate from small cell clusters known as polyps.
Colonoscopic surveillance and removal of polyps is an important strategy to prevent CRC …

Background Recent studies have shown that traditional serrated adenoma (TSA) can be
classified into BRAF and KRAS subtypes. Here, we examined the clinicopathological and …

Background Lynch syndrome (LS) is an autosomal dominant multi-organ cancer syndrome
with a high lifetime risk of cancer. The number of cumulative colorectal adenomas in LS …

In sessile serrated lesions (SSLs) with adenomatous dysplasia, the dysplastic component
and the serrated component without dysplasia should be considered as part of the same …