To define the systemic neuroimmune interactions in health and disease, we recently
suggested immunoception as a term that refers to the existence of bidirectional functional …

Somatosensory afferents are traditionally classified by soma size, myelination, and their
response specificity to external and internal stimuli. Here, we propose the functional …

The transition from acute to chronic pain is critically important but not well understood. Here,
we investigated the pathophysiological mechanisms underlying the transition from acute to …

Chronic pain affects 20% of adults and is one of the leading causes of disability worldwide.
Women and girls are disproportionally affected by chronic pain. About half of chronic pain …

Understanding the endogenous mechanisms regulating resolution of pain may identify
novel targets for treatment of chronic pain. Resolution of chemotherapy-induced peripheral …

Pain involves neuroimmune crosstalk, but the mechanisms of this remain unclear. Here we
showed that the splenic T helper 2 (TH2) immune cell response is differentially regulated in …

Our understanding of the role of innate and adaptive immune cell function in brain health
and how it goes awry during aging and neurodegenerative diseases is still in its infancy …

Progress in neuroimmunology established that the nervous and the immune systems are
two functionally related physiological systems. Unique sensory and immune receptors …

Novel disease-modifying treatments for neuropathic pain are urgently required. The cellular
immune response to nerve injury represents a promising target for therapeutic development …

Abstract Background Neutrophil extracellular traps (NETs) promote neuroinflammation and,
thus, central nervous system (CNS) disease progression. However, it remains unclear …