Type 2 diabetes mellitus (T2DM) is associated with increased total plasma free fatty acid
(FFA) concentrations and an elevated risk of cardiovascular disease. The exact mechanisms …

Type 2 diabetes mellitus (T2DM) is a complex, chronic and progressive metabolic disease,
which is characterized by relative insulin deficiency, insulin resistance, and high glucose …

Metformin, one of the oldest oral antidiabetic agents and still recommended by almost all
current guidelines as the first-line treatment for type 2 diabetes mellitus (T2DM), has become …

Central nervous system (CNS) diseases, both traumatic and neurodegenerative, are
characterized by impaired mitochondrial bioenergetics and often disturbed mitochondrial …

Late-onset Alzheimer's disease (LOAD) is the most frequent cause of dementia in older
persons. Subjects affected by type 2 diabetes mellitus (T2DM) are at higher risk of vascular …

Aging is a risk factor for major central nervous system (CNS) disorders. More specifically,
aging can be inked to neurodegenerative diseases (NDs) because of its deteriorating impact …

Biguanides are compounds in which two guanidine moieties are fused to form a highly
conjugated system. Biguanides are highly basic and hence they are available as salts …

This study aimed to expand our understanding of metformin (Met) in inhibiting hepatocellular
carcinoma (HCC) progression and to investigate its underlying mechanism. Met was …

Monitoring blood glucose levels for diabetic patients is critical to achieve tight glycaemic
control. As none of the current antidiabetic treatments restore lost functional β-cell mass in …

In recent years, the study of NOD-like receptor thermal protein domain associated protein 3
(NLRP3) inflammasome has become a hot topic, especially its role in various tumors. The …