Methodological challenges of genome-wide association analysis in Africa
Medical research in Africa has yet to benefit from the advent of genome-wide association
(GWA) analysis, partly because the genotyping tools and statistical methods that have been …
(GWA) analysis, partly because the genotyping tools and statistical methods that have been …
Polygenic risk scores for disease risk prediction in Africa: current challenges and future directions
Early identification of genetic risk factors for complex diseases can enable timely
interventions and prevent serious outcomes, including mortality. While the genetics …
interventions and prevent serious outcomes, including mortality. While the genetics …
DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West Africans
We investigated the role of DC-SIGN (CD209), long pentraxin 3 (PTX3) and vitamin D
receptor (VDR) gene single nucleotide polymorphisms (SNPs) in susceptibility to pulmonary …
receptor (VDR) gene single nucleotide polymorphisms (SNPs) in susceptibility to pulmonary …
Equity in international health research collaborations in Africa: perceptions and expectations of African researchers
Introduction and method Africa is currently host to a number of international genomics
research and biobanking consortia, each with a mandate to advance genomics research …
research and biobanking consortia, each with a mandate to advance genomics research …
Challenges in biobank governance in Sub-Saharan Africa
C Staunton, K Moodley - BMC medical Ethics, 2013 - Springer
Background Biological sample and data transfer within and out of Africa is steeped in
controversy With the H3Africa project now aiming to establish biobanks in Africa, it is …
controversy With the H3Africa project now aiming to establish biobanks in Africa, it is …
[HTML][HTML] A call for global governance of biobanks
H Chen, T Pang - Bulletin of the World Health Organization, 2014 - SciELO Public Health
The progress in genomic research has led to increased sampling and storage of biological
samples in biobanks. Most biobanks are located in high-income countries, but the …
samples in biobanks. Most biobanks are located in high-income countries, but the …
Genetic studies of African populations: an overview on disease susceptibility and response to vaccines and therapeutics
Africa is the ultimate source of modern humans and as such harbors more genetic variation
than any other continent. For this reason, studies of the patterns of genetic variation in …
than any other continent. For this reason, studies of the patterns of genetic variation in …
Establishment of a biobank and pharmacogenetics database of African populations
Pharmacogenetics and genomics research has experienced great advances over the past
decade as witnessed by the completion of the human genome in 2003 (www. genome …
decade as witnessed by the completion of the human genome in 2003 (www. genome …
Biobanks in developing countries: needs and feasibility
* Estimated, in US dollars.† This is 75% of the Estonian population.‡ For a pilot project of
10,000 participants. § Familial linkage studies are possible for these two biobanks, and …
10,000 participants. § Familial linkage studies are possible for these two biobanks, and …
The prevalence and distribution of the amyloidogenic transthyretin (TTR) V122I allele in Africa
DR Jacobson, AA Alexander, C Tagoe… - … Genetics & Genomic …, 2016 - Wiley Online Library
Abstract Background Transthyretin (TTR) pV 142I (rs76992529‐A) is one of the 113 variants
in the human TTR gene associated with systemic amyloidosis. It results from a G to A …
in the human TTR gene associated with systemic amyloidosis. It results from a G to A …