Synopsis Sevoflurane is an ether inhalation general anaesthetic agent with lower solubility
in blood than isoflurane or halothane but not desflurane. The low solubility and the absence …

General anesthetics threaten cardiovascular stability by causing changes in cardiac
function, vascular reactivity, and cardiovascular reflexes and significantly alter distribution of …

Functional magnetic resonance imaging (fMRI) in anesthetized rodents has been commonly
performed with α-chloralose, which can be used only for terminal experiments. To develop a …

There is now strong evidence that an endothelial mechanism, other than nitric oxide or
prostacyclin, exists for dilating arteries and arterioles. This third pathway has been named …

Besides cyclooxygenase and NO-synthase, another distinct endothelial pathway,
endothelium-dependent hyperpolarization (EDHF), is involved in the relaxation of the …

The advances made in vascular biology in the last 25 years have considerably changed the
perception that one could have of the endothelial cells. Once considered as a diffusion …

In humans, endothelial vasodilator function serves as a surrogate marker for cardiovascular
health and is measured as changes in conduit artery diameter after temporary ischemia [flow …

There has been an explosive increase in the amount of interesting information about the
physiologic and pathophysiologic roles of nitric oxide in cardiovascular, nervous, and …

Background The authors recently demonstrated that acetylcholine-induced pulmonary
vasorelaxation had two primary components, nitric oxide (NO) and endothelium-derived …

Background The mechanism by which propofol selectively attenuates the pulmonary
vasodilator response to acetylcholine is unknown. The goals of this study were to identify the …