Serpins are a superfamily of proteins, whose membership is based on the presence of a
single common core domain consisting of three β-sheets and 8-9 R-helices, and with a set of …

Diabetic retinopathy continues to be the leading cause of legal blindness among working-
age individuals. The earliest histological features of diabetic retinopathy include neuroretinal …

In the absence of disease, the vasculature of the mammalian eye is quiescent, in part
because of the action of angiogenic inhibitors that prevent vessels from invading the cornea …

Osteogenesis imperfecta (OI) is a heterogeneous genetic disorder characterized by bone
fragility and susceptibility to fractures after minimal trauma. After mutations in all known OI …

Adult stem cells are characterized by self-renewal and multilineage differentiation, and these
properties seem to be regulated by signals from adjacent differentiated cell types and by …

The potent actions of pigment epithelium-derived factor (PEDF) on tumour-associated cells,
and its extracellular localization and secretion, stimulated research on this multifunctional …

Pigment epithelium-derived factor (PEDF) is a potent and broadly acting neurotrophic factor
that protects neurons in many regions of the central nervous system against insults such as …

Increasing evidence suggest that exosomes from mesenchymal stem cells have therapeutic
effects in cerebral ischemia-reperfusion (I/R) injury, but the underlying mechanisms are …

purpose. To determine the effect of pigment epithelium-derived factor (PEDF) in a mouse
model of ischemia-induced retinal neovascularization and on vascular endothelial growth …

Plasma levels of high density lipoprotein cholesterol (HDL-C) are inversely proportional to
the incidence of cardiovascular disease. Recent applications of modern proteomic …