In the last few years, the understanding of the molecular basis of sickle cell disease has
progressed rapidly. It is now possible to describe the structure of the gel of polymerized …

Since the age of the Greeks, when it was assumed that the universe could be “explained” in
terms of fundamental particles and the void, scientists have been attempting to reduce …

Recent interest in therapies for sickle cell anemia based on elevating fetal Hb has made
accurate estimates of the sparing effect of fetal Hb (Hb F) and other non-sickle Hbs on sickle …

Introduction Sickle cell disease (SCD) is a debilitating inherited disorder that affects millions
worldwide. Four novel SCD therapeutics have been approved, including the hemoglobin …

With the Technical Assistance of Bak C. Kim abstract: The effects of 42/3-aryl-substituted
alanines on the inhibition of gelation of sickle hemoglobin (Hb S) were evaluated. These …

In this paper molecular quantum similarity measures (MQSM) are used to describe
molecular toxicity and to construct Quantitative Structure-Toxicity Relationships (QSTR) …

Several reviews describe the various types of low molecular-mass organic gelators (ie,
LMOGs, gelators that are primarily organic in composition and whose molecular mass is …

The interaction of human hemoglobin with several organic solvents and metal cation has
been studied in order to obtain selective precipitation of hemoglobin from solution. Alcohols …

5-Bromotryptophan (5-BrTrp) is the most potent amino acid derivative reported in the
literature to inhibit the gelation of hemoglobin S (from sickle cell anemia patients). Trp-Trp is …

N-Phenylacetyl-L-phenylalanine (PAP) and L-phenylalanyl-3-aminopyridine (PAPA) are
biaromatic agents with properties that make them suitable candidates for the development of …