The epidemic of the century, Diabetes Mellitus (DM) is continuously rising. Intensive
research is urgently needed whereby experimental models represent an essential tool to …

The reproducibility crisis (or replication crisis) in biomedical research is a particularly
existential and under-addressed issue in the field of behavioral neuroscience, where, in …

Improving the reproducibility of biomedical research is a major challenge. Transparent and
accurate reporting is vital to this process; it allows readers to assess the reliability of the …

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social
communication deficits and other behavioral abnormalities. The three-chamber social …

Objectives: The biological mechanisms linking diet-related obesity and depression remain
unclear. Therefore, we examined the impact of high-fat diet (HFD) on murine behaviour …

Animal models of neurodegenerative and neuropsychiatric disorders require extensive
behavioral phenotyping. Currently, this presents several caveats and the most important …

The manner in which laboratory rodents are housed is driven by economics (minimal use of
space and resources), ergonomics (ease of handling and visibility of animals), hygiene, and …

Anhedonia is described as a decreased ability to experience rewarding and enjoyable
activities, a core symptom of major depressive disorder. The sucrose preference test (SPT) is …

In light of the hotly discussed 'reproducibility crisis', a rethinking of current methodologies
appears essential. Implementing multi-laboratory designs has been shown to enhance the …

In response to NIH initiatives to investigate sex as a biological variable in preclinical animal
studies, researchers have increased their focus on male and female differences in …