Insulin is the paramount anabolic hormone, promoting carbon energy deposition in the
body. Its synthesis, quality control, delivery, and action are exquisitely regulated by highly …

Upon its secretion from pancreatic β-cells, insulin reaches the liver through the portal
circulation to exert its action and eventually undergo clearance in the hepatocytes. In …

The discovery of the carcinoembryonic antigen (CEA) as a tumor marker for colorectal
cancer some 50 years ago became the first step in the identification of a much larger family …

Over 65% of people with obesity display the metabolic-associated fatty liver disease
(MAFLD), which can manifest as steatohepatitis, fibrosis, cirrhosis, or liver cancer. The …

Insulin action is impaired in type 2 diabetes. The functions of the hormone are an integrated
product of insulin secretion from pancreatic β-cells and insulin clearance by receptor …

Plasma insulin clearance is an important determinant of plasma insulin concentration. In this
review, we provide an overview of the factors that regulate insulin removal from plasma and …

ABSTRACT CEACAM1 is an extensively studied cell surface molecule with established
functions in multiple cancer types, as well as in various compartments of the immune system …

Hyperinsulinemia is the hallmark of insulin resistance in obesity, and the relative importance
of insulin clearance, insulin resistance, and insulin hypersecretion has been widely debated …

There is wide variance among individuals in the fraction of insulin cleared by the liver (20%
to 80%). Hepatic insulin clearance is 67% lower in African Americans than European …

Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a
transmembrane glycoprotein that is expressed on epithelial, endothelial and immune cells …