Medicinal plants have been used by mankind since ancient times, and many bioactive plant
secondary metabolites are applied nowadays both directly as drugs, and as raw materials …

Plant specialized metabolites (PSMs) play essential roles in the adaptation to harsh
environments and function in plant defense responses. PSMs act as key components of …

Plant genomes remain highly fragmented and are often characterized by hundreds to
thousands of assembly gaps. Here, we report chromosome-level reference and phased …

Medicinal plants produce valuable secondary metabolites with anticancer, analgesic,
anticholinergic or other activities, but low metabolite levels and limited available tissue …

Camptothecin is a chemotherapeutic drug widely used to treat various cancers. Ophiorrhiza
pumila is an ideal plant model for the study of camptothecin production, with various …

The acceptance of new crop varieties by consumers is contingent on the presence of
consumer-preferred traits, which include sensory attributes, nutritional value, industrial …

The limited bioavailability of plant-derived natural products with anticancer activity poses
major challenges to the pharmaceutical industry. An example of this is camptothecin, a …

The plant kingdom is a rich source of bioactive compounds, many of which have been used
since pre-history for their therapeutic properties to treat a range of illnesses. These …

Abstract Camptothecin (CPT), a well-known natural anti-cancer drug, is produced from
woody plant Camptotheca acuminata. Up to now, two CPT-derivatives, irinotecan and …

Abstract Camptothecin (CPT), a well-known monoterpenoid indole alkaloid with broad-
spectrum anti-cancer activity, is produced from plants and endophytes. In view of the …